Translational Medicine Director/Associate*- Cardiovascular & Metabolic

Novartis; Basel; Hybrid; CHF 123.000 - 280.000; Vollzeit

Benefits dieser Stelle

Flexible and hybrid working options

14 weeks parental leave

Insurance, retirement, wellbeing and全球

Zusammenfassung

Novartis is seeking a TM Expert in Cardiovascular Metabolism to lead PoC strategies and drive cross-functional teams through PoC and early development. You will interact with biology, chemistry, and clinical operations to shape development pathways.

The role requires MD with subspecialty, 1–2 years in pharma/biotech and a track record of scientific leadership, with strong English communication. Flexible, hybrid working options are offered along with broad total rewards.

Qualifikationen

• MD with clinical subspecialty in cardiovascular disease or endocrinology/metabolic disease.
• At least 1–2 years in pharma/biotech/CRO or academic medical center; 5+ years for Director level.
• Excellent written and oral communication, publications in international journals.
• Fluent English, able to work in a matrix, cross-functional environment.

Aufgaben

• Lead global project teams through PoC phase and beyond.
• Own Integrative Development Plan components through PoC.
• Act as medical monitor for one or more studies.
• Communicate clinical matters to project teams and decision boards.
• Convene internal/external leaders to discuss PoC approach.
• Evaluate clinical centers and collaborate with investigators.
• Oversee publication and external presentation of PoC results.
• Accountable for biomarker strategies; work with biomarker experts.
• Identify and implement preclinical strategies for program objectives.
• Present to Health Authorities as TM Expert.

Kenntnisse

English fluency

Communication

Independence

Leadership

Innovation

Clinical research

Ausbildung

MD with subspecialty training

PhD or post-doctoral research

Jobbeschreibung

Summary

Novartis BioMedical Research (BR) is the innovation engine of Novartis that collaborates across the company and beyond, focusing on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients. Translational Medicine (TM) is the clinical research arm of Novartis BR, and includes about 900 associates globally. TM plays a pivotal role in bringing innovative medicines to patients, by building on research advances to develop new therapies, and bridging drug discovery and clinical application.

TM Discovery & Profiling Overview

The TM Discovery & Profiling (TMDP) is a group of physicians and clinical researchers who drive innovative science from discovery to the patient through the selection, profiling, and effective development of medicines. Translational medicine experts oversee Phase 1 and 2 clinical trials to demonstrate proof-of-mechanism and proof-of-concept (PoC) in patients, as well as support for later Phase 3 development. Translational medicine experts are key and highly visible members of global cross-functional project teams that design and implement early research and discovery projects, that then culminate in clinical PoC studies. Translational medicine experts collaborate with colleagues in biology and chemistry to identify targets in diseases with significant unmet medical needs and provide input on likely clinical development pathways. The early clinical trials led by our translational medicine experts are among the most critical steps in drug development at Novartis. After PoC and if the program proceeds to full development, the translational medicine expert continues as a key member of the full development team up to and including registration.

Role Overview

As a Cardiovascular Metabolism (CVM) TM Expert, you will collaborate with the CVM TM Head or other experienced TM Experts to develop high value decision-strategies for the Translational Medicine component of drug development projects and to lead global cross-functional project teams through the PoC phase and beyond.

TME Director Cardiovascular Metabolism

Oversees the planning, execution, and interpretation of clinical trials research, data collection activities and clinical operations, serving a leadership role in the matrixed trial team. Establishes and approves scientific methods for design and implementation of clinical protocols, data collection systems and final reports. Support new and ongoing clinical research and clinical trials and ensure efficient and timely processing of confidentiality agreements and clinical agreements

Key Responsibilities

• Lead global project teams through PoC phase to drive implementation of the PoC strategy; participate in project teams through program life cycle from NTRC to registration
• Responsible for clinical portions of the Integrated Development Plan (IDP) through PoC.
• Acts as medical monitor for one or more clinical studies.
• Communicate clinical team matters to project teams and relevant decision boards (such as the Disease Area Decision Board).
• Convene relevant (internal and external) leaders to consider proposed approach to PoC.
• Evaluate clinical centers and foster communication with crucial collaborating investigators.
• Oversee publication and external presentation of PoC clinical study results.
• Accountable for compound related biomarker strategies; work closely with biomarker experts in implementation.
• In collaboration with research scientists identify, develop and implement strategy for preclinical support of program related objectives; this includes assessment of medical need, proposal of clinical development pathways, and review of preclinical data for clinical implications and other relevant activities
• Participate in team presentations to Health Authorities as TM Expert

Essential Requirements

• Doctoral degree, MD required with clinical subspecialty training preferred in cardiovascular disease or endocrinology/metabolic disease; Additional PhD/post-doctoral equivalent research preferred.
• At least 1-2 years' experience in a pharmaceutical/biotech company, CRO, or academic medical center, or related experience; 5 plus years to be considered for Director level.
• Recognized for medical expertise.
• Recognized for scientific expertise and passion for science: respected by colleagues internally and externally, having made significant contributions to the field and created / established new concepts; record of high quality publications in international scientific journals.
• Excellent written and oral communication/presentation skills.
• Independence: Able to work independently on study planning and execution, and with supervision on project planning.
• Leadership of Collaborations: Able to lead multidisciplinary teams in a matrix organization.
• Innovation: Seeks out new clinical discovery opportunities and PoC approaches.
• Additional consideration for candidates with advanced research experience in data science, genetics/genomics, artificial intelligence applied to clinical research, or digital/wearable health science.
• Fluent oral and written English
• This is a dual level posting. The final level & title of the offer role would be determined by the hiring team based on the skills, experience & capabilities required to perform the role at the level the role has been offered.

The base salary offered is determined based on gender-neutral objectives, such as relevant skills, competencies and experience in accordance with the Novartis pay setting policy and upon joining Novartis will be reviewed periodically.

Associate Director: 122,500.00 - 175,000.00 - 227,500.00 CHF Annual

Director: 150,500.00 - 215,000.00 - 279,500.00 CHF Annual

In addition to your base salary, you may be eligible for a performance-based bonus depending on certain performance parameters.

The rewards of being part of our team go far beyond base pay and incentives. We also offer a variety of competitive benefits in kind to help you thrive personally and professionally, such as insurance plans, retirement plans, wellbeing resources and global recognition programs. In addition, we provide flexible and hybrid working options, where possible, and minimum 14 weeks paid parental leave.

Pay equity is a fundamental principle of our employment policy and reflects our commitment to create a diverse, equitable and inclusive environment that treats all employees with dignity and respect, as outlined in our Code of Ethics.

Read our brochure to learn more about our global total rewards offering:

https://www.novartis.com/sites/novartis_com/files/novartis-life-handbook.pdf

Note: Benefits and compensation may vary by country and are subject to local legal requirements, including provisions of collective bargaining agreements where applicable. A full overview of your compensation package, including any relevant collective bargaining agreement details applicable to your role based on your employment location and Novartis employer entity, will be communicated separately to you during the application process.

Why Novartis

Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture

Benefits and Rewards

Learn about all the ways we’ll help you thrive personally and professionally.

Read our handbook (PDF 30 MB)