Scientist Synthesis Automation

Roche; Basel; Vor Ort; CHF 120.000 - 150.000; Vollzeit

Zusammenfassung

Roche's Medicinal Chemistry team in Basel is seeking a Scientist to accelerate compound synthesis through automation and digitalization, focusing on parallel chemistry and late-stage functionalization. You will introduce new synthetic methodologies, reaction miniaturization, and integrated analytics, generating high-quality datasets for machine learning while collaborating across global discovery teams.

A PhD in Synthetic Organic Chemistry with at least four years of industry experience is

Qualifikationen

• PhD in Synthetic Organic Chemistry with 4+ years industry experience.
• Strong expertise in automation and liquid handling in labs.
• Experience in parallel synthesis and late-stage functionalization.
• Experience with data collection for machine learning in chemistry.
• Excellent communication and cross-functional collaboration.

Aufgaben

• Accelerate compound synthesis through automation and digitalization.
• Expand and execute synthetic technologies like parallel chemistry.
• Introduce new synthetic methodologies and miniaturization.
• Contribute to high-quality reaction datasets for ML.
• Lead matrix teams and manage stakeholder relationships.

Kenntnisse

Automation

Solid dosing

Liquid handling

Analytical purification

Synthetic methodology

Digitalization

Machine learning

Reaction prediction

Parallel medicinal chemistry

Cross-functional collaboration

Stakeholder management

Agile project management

Communication skills

Leadership in matrix teams

Ausbildung

PhD in Synthetic Organic Chemistry

Tools

Automated synthesis equipment

Jobbeschreibung

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.

The Position

In Roche’s Pharmaceutical Research and Early Development organization (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility, and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

Therapeutic Modality (TMo) organization, accountable for translating disease biology into high-quality drug candidates across small molecules, large molecules, oligonucleotides, and genomic medicines. By integrating deep modality expertise with cross-disciplinary collaboration, TMo drives innovation within and across platforms to enable differentiated, sustainable therapeutic impact.

The Medicinal Chemistry Team in Pharma Research and Early Development, located in Basel, is part of Small Molecule Research. We are a community of drug hunters with expertise in synthesis, design and purification, with a responsibility to convert hypotheses into innovative small molecules for treating diseases of high unmet medical need, closely collaborating with our broader therapeutic areas and functions. In your role, you will be working on accelerating compound synthesis through automation and digitalization as part of the Dolphin team. You will be focusing on expanding and executing synthetic technologies (e.g., parallel chemistry and late-stage functionalization).

The opportunity

In your role as a Scientist within Medicinal Chemistry, you will be working on accelerating compound synthesis through automation and digitalization as part of the Dolphin team. You will be focusing on expanding and executing synthetic technologies (e.g., parallel chemistry and late-stage functionalization). This requires the introduction of new synthetic methodologies and techniques, including reaction miniaturization, photochemical transformations, small-scale purification and analytical methodology development. Thereby you will also contribute to generating high-quality reaction datasets for machine learning applications.

Who you are

You possess a very strong background in synthetic organic chemistry and laboratory digitalization to accelerate the synthesis of chemical matter for Medicinal Chemistry, ideally with a PhD in Synthetic Organic Chemistry with at least four years of industry experience. In particular:

• You have expertise in automation technology, including solid dosing and liquid handling, integrated with analytical and purification methodologies
• You have a strong background in synthetic methodology development and hands-on laboratory experimentation in small molecule synthesis
• You have experience in assessing and implementing digitalization and automation solutions in chemical laboratoriesli>
• You understand machine learning concepts for reaction prediction and have experience in collecting reaction datasets
• You have experience in applying parallel medicinal chemistry approaches to solve medicinal chemistry problems.
• You have experience in cross-functional and international relationship building within a large discovery organization including stakeholder management and academic collaborations
• You have demonstrated agile distribution and prioritization of work packages between internal and CRO-based teams
• You have excellent communication and presentation skills, along with strong interpersonal abilities with a track record of leading matrix teams without positional authority

At Roche, we aim high to deliver life-changing healthcare solutions. If you’re ready to make a meaningful impact on patients and healthcare systems worldwide, this is the place for you.

Who we are

A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.

Let’s build a healthier future, together.

Roche is an Equal Opportunity Employer.