Subject Matter Expert Solid State Science

F. Hoffmann-La Roche AG; Basel; Vor Ort; CHF 120.000 - 150.000; Vollzeit

Zusammenfassung

F. Hoffmann-La Roche AG in Basel is seeking a Subject Matter Expert to lead solid-state strategy and optimize the solid-state form of drug candidates within the Pharmaceutical Research and Early Development (pRED) organization. You will coordinate complex screening and characterization activities across internal laboratories and global external partners.

The ideal candidate holds a Ph.D. and brings a strong focus on solid-state characterization and the ability to manage external relationships effectively. Roche values a proactive, solution-oriented approach in a fast-paced R&D environment.

Qualifikationen

• Ph.D. in Pharmaceutical Sciences, Chemistry, Material Science, or a related field.
• Strong focus on solid-state characterization and crystallization.
• Deep understanding of solid-state analytical techniques.

Aufgaben

• Lead the identification of the optimal solid-state form for drug candidates.
• Coordinate screening and characterization across laboratories.
• Drive cross-functional efforts to develop the 'Golden Form' of therapies.

Kenntnisse

Solid-state characterization

Crystallization

Project management

Communication skills

Digital solution implementation

Ausbildung

Ph.D. in Pharmaceutical Sciences or related field

Tools

XRD

DSC

TGA

DVS

Microscopy

Jobbeschreibung

Position Overview

At Roche, we are seeking a Subject Matter Expert to lead solid‑state strategy and optimize the solid‑state form of drug candidates within our Pharmaceutical Research and Early Development (pRED) organization.

Responsibilities

• Lead the identification of the optimal solid‑state form, ensuring early‑stage candidates possess the necessary solubility and stability for clinical success.
• Serve as the central hub, coordinating complex screening and characterization activities across internal laboratories and global external partners.
• Lead cross‑functional efforts to de‑risk drug candidates and define the "Golden Form" that advances therapies from the lab to patients.
• Act as the single point of accountability for the solid‑state strategy of assigned projects, selecting optimal salt, polymorph, and particle forms to support stability and bioavailability.
• Assume full responsibility for lifecycle management of materials, from integration of biopharmaceutical assessments to definition of robust crystallization processes.
• Orchestrate the interface between Chemistry, Analytics, and Formulation teams to harmonize the material‑science narrative throughout the drug development lifecycle.
• Evaluate, vet, and select global external CRO/CMO partners; manage collaborations and ensure data generation meets rigorous quality and milestone standards.
• Explore and champion digitalization and automated screening tools to enhance data analysis throughput and accelerate project cycle times.
• Manage the balance between internal technical services and external outsourcing partners, ensuring high‑quality data generation and proactive risk mitigation.

Qualifications

• Ph.D. in Pharmaceutical Sciences, Chemistry, Material Science, or a closely related field.
• Strong focus on solid‑state characterization and crystallization.
• Deep understanding of solid‑state analytical techniques (XRD, DSC, TGA, DVS, microscopy) and their application in pharmaceutical development.
• Proven ability to lead complex projects in a matrix environment and translate technical data into strategic decisions for non‑expert stakeholders.
• Experience managing external CRO/CMO relationships and driving process improvements, including digital solution implementation.
• Proactive, solution‑oriented approach with strong communication skills and adaptability to a fast‑paced R&D environment.

Roche is an Equal Opportunity Employer.