Senior Antibody Discovery Lead - Display & Biophysics

IGI; Épalinges; On-site; CHF 120,000 - 180,000; Full time

Job summary

IGI is seeking a scientist to join its Antibody Discovery and Engineering team in Lausanne, Switzerland. The role focuses on hands-on antibody display, library design, and high-throughput screening to advance next generation multispecific antibodies.

Strong molecular biology and biophysical skills are essential. You will drive campaigns using phage, yeast, or mammalian display, perform sequence analysis, and collaborate across discovery teams to meet project milestones.

Qualifications

• PhD or MSc in biotech/biochem with 5+ years in industry preferred.
• Hands-on experience with antibody display platforms (phage/yeast/mammalian).
• Proficiency in molecular biology and DNA sequence analysis.
• Experience with protein expression and biophysical characterization (SDS-PAGE, SEC).
• Experience with SPR or BLI for protein interactions is a plus.

Responsibilities

• Design and generate novel antibody libraries for display platforms.
• Lead antibody discovery campaigns using display technologies.
• Perform high-throughput screening with SPR, ELISA, and flow cytometry.
• Analyze antibody sequences (Sanger/NGS).
• Clone, express, and purify therapeutic antibodies.
• Characterize candidates by analytical methods (SDS-PAGE, SEC, DSF).
• Develop protein-protein interaction assays (kinetic, epitope binning, ELISA, SPR, BLI).
• Support project timelines and communicate progress to management.

Skills

Phage display

Yeast display

Mammalian display

SPR/BLI binding assays

Protein expression

Education

PhD in Biotechnology/Biochemistry

MSc in a related field

Tools

DNA sequencing (Sanger/NGS)

RNA extraction & RT-PCR

Protein purification

Job description

IGI is seeking a scientist to join its Antibody Discovery and Engineering team in Lausanne, Switzerland. The role focuses on hands-on antibody display, library design, and high-throughput screening to advance next generation multispecific antibodies.

Strong molecular biology and biophysical skills are essential. You will drive campaigns using phage, yeast, or mammalian display, perform sequence analysis, and collaborate across discovery teams to meet project milestones.