Principal Scientist - Lead Identification

IGI; Épalinges; In loco; CHF 120.000 - 180.000; Tempo pieno

Descrizione del lavoro

IGI is seeking a scientist to join its Antibody Discovery and Engineering team in Lausanne, Switzerland. The role focuses on hands-on antibody display, library design, and high-throughput screening to advance next generation multispecific antibodies.

Strong molecular biology and biophysical skills are essential. You will drive campaigns using phage, yeast, or mammalian display, perform sequence analysis, and collaborate across discovery teams to meet project milestones.

Competenze

• PhD or MSc in biotech/biochem with 5+ years in industry preferred.
• Hands-on experience with antibody display platforms (phage/yeast/mammalian).
• Proficiency in molecular biology and DNA sequence analysis.
• Experience with protein expression and biophysical characterization (SDS-PAGE, SEC).
• Experience with SPR or BLI for protein interactions is a plus.

Mansioni

• Design and generate novel antibody libraries for display platforms.
• Lead antibody discovery campaigns using display technologies.
• Perform high-throughput screening with SPR, ELISA, and flow cytometry.
• Analyze antibody sequences (Sanger/NGS).
• Clone, express, and purify therapeutic antibodies.
• Characterize candidates by analytical methods (SDS-PAGE, SEC, DSF).
• Develop protein-protein interaction assays (kinetic, epitope binning, ELISA, SPR, BLI).
• Support project timelines and communicate progress to management.

Conoscenze

Phage display

Yeast display

Mammalian display

SPR/BLI binding assays

Protein expression

Formazione

PhD in Biotechnology/Biochemistry

MSc in a related field

Strumenti

DNA sequencing (Sanger/NGS)

RNA extraction & RT-PCR

Protein purification

Descrizione del lavoro

The successful candidate will join an innovative Antibody Discovery and Engineering department with a strong record of success in developing novel antibody therapeutics in the field of immune-oncology and autoimmune diseases. We are looking for a motivated and talented scientist with deep understanding and strong hands‑on experience in antibody display technologies, antibody expression and biophysical characterization to support the discovery of next generation MultispecificTM antibodies.

RESPONSIBILITIES:

• Contribute to the development of antibody discovery platform by designing and generating novel antibody libraries for phage, yeast or mammalian display applications.
• Lead and perform antibody discovery campaign using phage, yeast or mammalian display.
• Perform high-throughput screening of antibodies using techniques such as surface plasmon resonance (SPR), ELISA, or flow cytometry.
• DNA sequence analysis of selected antibodies (Sanger or NGS)
• Clone, express, and purify therapeutic antibodies.
• Characterize antibody candidates using analytical methods (e.g. SDS-PAGE, SEC, DSF, AC-SINS, polyreactivity) and flow-cytometry.
• Develop and perform protein-protein interaction assays, including kinetic, epitope binning, blocking assays (ELISA, SPR, BLI)
• Participate in streamlining antibody discovery processes by implementing new technologies and adopting AI/ML.
• Effectively support projects and accomplish goals under project timelines.
• Interface with multiple discovery project and matrix teams across the organization
• Effectively communicate research progress and opportunities to senior management
• Support a culture that embraces scientific excellence, continuous learning, and increasing team’s ability to deliver novel drug candidates

EDUCATION AND DESIRED EXPERIENCE:

• Ph.D. entry level or MSc degree in biotechnology, biochemistry or related discipline is required. At least 5 years of relevant industrial experience is preferred.
• Hands‑on experience with protein engineering using display systems (phage, yeast or mammalian display) is required.
• Proficiency in molecular biology techniques (RNA extraction, RT-PCR, PCR, cloning, primer design) and DNA sequence analysis software is required.
• Experience with protein expression and characterization (e.g. SDS-PAGE, SEC) is required.
• Experience with protein-protein interaction technologies (e.g. SPR/BLI) would be a plus.
• Strong English communication skills, both oral and written
• Rigorous, excellent organization skills, autonomous, hands‑on and team minded
• Strong interpersonal communication skills and the ability to present to all levels of the organization
• Proven experience in problem analysis/solving
• Proactive, reactive and adaptable

LOCATION:

You will join us, a vibrant biotech community at the Biopôle (https://www.biopole.ch/) overlooking the beautiful shores of Geneva lake in Lausanne, Switzerland.