Research Scientist / Senior Scientist – Protein Sciences (Novartis Biomedical Research)

Novartis Farmacéutica; Basel-Stadt; Vor Ort; CHF 90’000 - 120’000; Vollzeit

Zusammenfassung

A leading company in biopharmaceuticals is seeking a Research Scientist / Senior Scientist in Protein Sciences to join their dynamic Discovery Sciences team in Basel. The role entails high-level protein expression and purification aimed at drug discovery. Ideal candidates will have a background in protein biochemistry, teamwork abilities, and experience in an industrial research environment.

Qualifikationen

• Completed apprenticeship as a laboratory technician with 2 years of practical experience.
• In-depth knowledge in protein biochemistry, including expression and purification.
• Familiarity with cryo-EM workflows and industrial research environments.

Aufgaben

• Produce high-quality proteins for drug discovery.
• Purify proteins using chromatography techniques.
• Collaborate on cryo-EM structural characterization of membrane proteins.

Kenntnisse

Protein biochemistry

Collaboration

Communication

Organizational skills

Ausbildung

Bachelor/Master in biochemistry, biology, molecular biology, life sciences

Tools

PyMol

AlphaFold

Jobbeschreibung

Research Scientist / Senior Scientist – Protein Sciences (Novartis Biomedical Research)

Job ID REQ-10051508

Summary

Novartis Biomedical Research (BR) serves as the innovation engine of Novartis, driving cutting-edge approaches to deliver therapeutic breakthroughs for patients. Within BR, the Discovery Sciences department pioneers early-stage drug discovery and promotes innovative therapeutics to tackle challenging disease targets.
The Protein Sciences group in Discovery Sciences is an interdisciplinary team specializing in protein biochemistry, biophysics, NMR, X-ray crystallography, and electron microscopy. Our focus is to enable target-based hit identification, validation, and structure-guided drug discovery, with an emphasis on challenging targets such as membrane proteins.
We are seeking a highly skilled and motivated Research Scientist / Senior Scientist with a strong background in protein expression and purification, ideally including experience with membrane proteins, to join our team in Basel, Switzerland. This is a unique opportunity to contribute to drug discovery across multiple disease areas within a dynamic, collaborative environment that values curiosity, innovation, and teamwork.

About the Role

Responsibilities

You will work to produce high-quality proteins for drug discovery, focusing on small molecule hit generation, validation, and structural biology. Key responsibilities include:

• Express proteins insect and mammalian cell culture systems.
• Purify proteins using chromatography techniques and FPLC equipment to enable downstream assays and structural biology for drug discovery.
• Collaborate with team members to enable cryo-EM structural characterization of membrane proteins.
• Optimize protocols and processes through literature research, ideation and hands-on wet lab exploration.
• Work closely in a matrix setting with lab associates and present findings to project teams.
  
• Completed apprenticeship as a laboratory technician with 2 years of practical work experience or Bachelor/Masters in biochemistry, biology, molecular biology, life sciences, or a related field with strong experience in wet lab work.
• In-depth theoretical knowledge and hands-on experience in protein biochemistry, including expression, purification, and characterization.
• Strong collaboration, organizational, and communication skills in oral and written English, with the ability to effectively present results in team settings.
• Proactive interest in acquiring new techniques in protein biochemistry, biophysics, and structural biology.
  
• Hands-on experience in membrane protein expression, purification, characterization, and familiarity with cryo-EM workflows (sample preparation, grid handling).
• Prior exposure to an industrial research environment.
• Familiarity with software tools for structural analysis and AI driven protein construct design (PyMol, AlphaFold, etc.).

Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture

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Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.

Job ID REQ-10051508

Research Scientist / Senior Scientist – Protein Sciences (Novartis Biomedical Research)