Research Associate in vitro/ex vivo models in non-malignant hematology

Phirm.ch; Basel; On-site; CHF 90,000 - 130,000; Full time

Job summary

Roche in Basel is seeking a diligent Research Associate to join the non-malignant hematology group within pRED CM I2. You will design and execute in vitro and ex vivo experiments to evaluate novel therapies for bleeding disorders such as hemophilia and von Willebrand disease.

You will validate novel systems, apply confocal imaging, and collaborate closely with the team to interpret data and optimize test platforms for efficacy and safety assessments.

Qualifications

• MSc/BSc in Life Sciences or equivalent, plus 3+ years experience.
• Experience with confocal microscopy and live cell imaging.
• Experience with in vitro/ex vivo hemostasis models and related assays.

Responsibilities

• Validate and apply novel in vitro systems (e.g., organ-on-a-chip) for bleeding disorders.
• Apply imaging technologies to analyze in vitro test systems using patient plasma.
• Collaborate to design and interpret data on efficacy, safety and mode of action of novel therapies.
• Contribute to data capture, storage, and assay automation, and present findings in team meetings.

Skills

Confocal microscopy

Live cell imaging

Microfluidic systems

Data management

Teamwork

Education

Life Sciences degree (MSc/BSc)

Lehrabschluss apprenticeship

Tools

ELISA

Job description

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters. The PositionIn Roche’s Pharmaceutical Research and Early Development organization (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility, and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed. pRED Cardiovascular & Metabolism, Immunology and Infectious Diseases (CMI2), located in Basel, Switzerland, focuses on the discovery and early development of innovative treatments for specific diseases that affect the lives of millions. In the cardiovascular and metabolism area, we are developing cutting-edge therapies to treat metabolic diseases. The PositionWe’re currently looking for a diligent and highly motivated Research Associate to join our non-malignant hematology group. As part of a larger team, you will design and execute in vitro and ex vivo experiments to evaluate the efficacy, safety and mode of action of novel therapies for bleeding disorders such as hemophilia and Von Willebrand Disease. These responsibilities capture a portion of what your work will look like: Validate and apply novel in vitro systems (incl. microphysiological systems, organoids, “organ-on-a-chip”) for the assessment of new targets or therapeutic agents that can be leveraged to address bleeding disorders Apply state-of-the-art imaging technologies (e.g. confocal imaging) to the analysis of in vitro test systems utilizing patient plasma and blood Collaboratively design, execute, and interpret data from in vitro and ex vivo experiments, to assess the efficacy, safety and mode of action of novel therapies in the area of bleeding disorders Concisely present experimental data to the group during regular team meetings Continuously improve test systems, treatment, analysis, and data evaluation. Contribute to work process optimization including data capture, storage and assay automation Work closely with all members of the group, share duties, maintain a clean work environment and actively contribute to the positive work atmosphere within the group Who You Are You’re someone who wants to influence your own development. You enjoy teamwork, diligence and efficiency. You are looking for a company where you receive the opportunity to pursue your interests across functions and geographies. Working in a multi-cultural environment motivates you. As a fast learner you actively drive the quality of the requirements. MSc/BSc in Life Sciences (cellular/ molecular biology, pharmacology, immunology), or completion of an apprenticeship for a research associate (“Lehrabschluss”) with at least 3 years of relevant academic or industry experience Experience in confocal microscopy, live cell imaging, and microfluidic systems Technical and theoretical background/expertise in in vitro/ex vivo models of hemostasis and thrombosis (including thrombin generation and fibrinolysis assays) You communicate effectively in English, both in writing and orally. Skillfully able to interact with people and have strong commitment to teamwork. Excellent data management and record-keeping skills Experience with animal surgery, Experience in applying in vitro analytical technologies such as ELISAs and biochemical assays for data analysis and result evaluation, and prior industry experience are assets for this role At Roche, we aim high to deliver life-changing healthcare solutions. If you’re ready to make a meaningful impact on patients and healthcare systems worldwide, this is the place for you. Who we areA healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact. Let’s build a healthier future, together. Roche is an Equal Opportunity Employer.

Conditions

• Workload: 100%
• Place of work: Basel, BS

Workload: 100%