Principal Scientist, Respiratory Discovery

F. Hoffmann-La Roche AG; Basel; Vor Ort; CHF 180.000 - 240.000; Vollzeit

Zusammenfassung

Roche’s pRED CMI in Basel seeks a Principal Scientist in Respiratory Discovery to lead COPD target identification and validation through translational biology, pharmacology and team leadership. You will guide preclinical studies and drive programs toward early clinical development.

You will collaborate across disciplines, manage multidisciplinary teams, and mentor junior scientists while advancing innovative strategies to address COPD patient needs.

Qualifikationen

• PhD in Life Sciences with 5–10 years of pharma industry experience.
• Deep COPD biology expertise including tissue remodelling and inflammation.
• Proven publications in high-impact journals and strong collaboration record.

Aufgaben

• Lead translational COPD research to identify novel drug targets and therapeutic hypotheses.
• Direct preclinical studies for target validation and characterization.
• Advance targets into early drug discovery and manage multidisciplinary teams.
• Communicate findings to senior management and mentor junior scientists.

Kenntnisse

COPD biology

Target identification

Project leadership

Mentoring

Translational research

Ausbildung

PhD in Life Sciences

Jobbeschreibung

Principal Scientist, Respiratory DiscoveryIr para o conteúdo principal#Principal Scientist, Respiratory Discovery page is loaded## Principal Scientist, Respiratory DiscoveryCandidatar-selocations: Baseltime type: Tempo integralposted on: Publicado hojejob requisition id: 202607-117768Na Roche, você pode-se apresentar como você mesmo, abraçado pelas qualidades únicas que traz. Nossa cultura incentiva a expressão pessoal, o diálogo aberto e as conexões genuínas, onde você é valorizado e respeitado por quem você é, e permitindo que você prospere tanto pessoal como profissionalmente. É assim que pretendemos prevenir, deter e curar doenças e garantir que todos tenham acesso aos cuidados de saúde hoje e nas gerações futuras. Junte-se à Roche, onde cada voz é importante.### A posição In Roche’s Pharmaceutical Research and Early Development organisation (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility, and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.pRED Cardiovascular, Metabolism, Immunology (CMI), located in Basel, Switzerland, focuses on the discovery and early development of innovative treatments for specific diseases that affect the lives of millions. In the Immunology Department, we are developing cutting-edge therapies to treat chronic inflammatory diseases, including novel treatment options for chronic obstructive pulmonary disease (COPD). ### The OpportunityTo complement the Immunology team in pRED CMI, we are seeking a visionary, highly motivated, experienced Scientist with a strong academic background in pulmonary research, a track record in drug target identification and validation and proven ability to effectively lead projects in a drug discovery setting.As a Principal Scientist in pRED CMI, you will be a part of an international and multidisciplinary group of scientists and clinicians committed to delivering innovative solutions for COPD patients by combining cutting-edge approaches in biology, pharmacology and translational research. Key Responsibilities:* Utilising patient data and translational models, you will lead innovative initiatives to gain a better understanding of COPD pathobiology in order to identify novel drug targets and generate therapeutic hypotheses that are experimentally testable, druggable and clinically developable.* In collaboration with a dedicated team of lab-based associates and post-doctoral scientists, you will direct, oversee and interpret complex preclinical experimental studies for the validation and characterisation of targets or therapeutic agents in COPD.* You will bring targets into the early drug discovery pipeline and lead multidisciplinary teams up to clinical candidate generation.* Working in multidisciplinary teams, you will diligently evaluate external opportunities and clearly communicate the findings to senior management* People management, including coaching and mentoring junior scientists and postdocs### Who You Are* You hold a PhD degree in Life Sciences (respiratory biology, cellular/ molecular biology, pharmacology, immunology - or a closely related field) and bring 5 to 10 years of experience in the pharmaceutical industry.* You bring deep expertise in COPD disease biology, including chronic tissue remodelling, inflammation and/ or epithelial biology* You have significant scientific accomplishments and successful collaborations documented by publications in high-impact journals* You have a strong strategic thinking capacity, with the ability to balance multiple priorities in a fast-paced, matrixed organisation.* You have a good understanding of general pharmacological properties of therapeutic modalities such as small molecules and antibodies.* You can effectively communicate scientific data and concepts to colleagues, teams and senior management.At Roche, we aim high to deliver life-changing healthcare solutions. If you’re ready to make a meaningful impact on patients and healthcare systems worldwide, this is the place for you. ### Quem nós somosUm futuro mais saudável nos leva a inovar. Juntos, mais de 100 mil funcionários em todo o mundo se dedicam ao avanço da ciência, garantindo que todos tenham acesso à saúde hoje e nas próximas gerações. Nossos esforços resultam em mais de 26 milhões de pessoas tratadas com nossos medicamentos e mais de 30 bilhões de testes realizados usando nossos produtos de diagnóstico. Nós nos capacitamos para explorar novas possibilidades, promover a criatividade e manter as nossas ambições altas, para fornecer soluções de saúde que mudem a vida e causem um impacto global.Vamos construir juntos um futuro mais saudável.**A Roche é um empregador que pratica políticas de igualdade de oportunidades.**