Postdoctoral Position in Leukemia Immunology and Metabolism

1000scholars; Basel; Hybrid; CHF 85,000 - 110,000; Full time

Job summary

University of Basel in Basel, Switzerland seeks a dedicated postdoctoral researcher to lead an interdisciplinary project at the interface of leukemia biology, tumor immunology, and cellular metabolism.

You will design and perform mechanistic experiments, including in vivo leukemia models, metabolomics, CRISPR screens, and single-cell analyses; mentor PhD/MSc students; and contribute to manuscripts and grant proposals. Fluency in English and strong collaboration are essential.

Qualifications

• PhD in cancer biology, immunology, molecular biology, hematology, or related field.
• Hands-on experience with in vivo mouse tumor models, ideally hematological cancers.
• Strong background in tumor biology and/or immunology; English proficiency.
• High-quality first-author publication and ability to work independently.

Responsibilities

• Design, perform, and interpret mechanistic experiments, including in vivo studies.
• Establish and adapt experimental approaches as required and mentor students.
• Analyze and present scientific data; contribute to manuscripts and grant applications.
• Develop collaborative projects and participate in meetings and seminars.

Skills

Tumor immunology

In vivo mouse models

Flow cytometry

CRISPR screening

Scientific communication

Education

PhD in cancer biology or immunology

Tools

LC-MS metabolomics

Spectral flow cytometry

CRISPR screens

Job description

# Postdoctoral Position in Leukemia Immunology and MetabolismUniversity of BaselBasel, SwitzerlandPostdoctoralLeukemiaImmunologyMolecular BiologyNo deadline given## About the positionPostdoctoral Position in Leukemia Immunology and Metabolism University of Basel Basel, Switzerland Your position Research environment: The successful candidate will lead an ambitious interdisciplinary project at the interface of leukemia biology, tumor immunology, and cellular metabolism. Our ongoing work shows that leukemia metabolism profoundly influences the tumor-immune crosstalk, shaping both recognition of leukemia cells by the immune system and immune cell phenotypes. The project will investigate how specific metabolic programs enable leukemia cells to adapt to therapeutic and immune pressure, alter leukemia-immune interactions, and create targetable vulnerabilities. Research directions may include: Metabolic adaptation of leukemia under therapeutic pressure; Effects of leukemia-derived metabolites on immune-cell function and immune recognition; Identification and functional validation of metabolic mechanisms and therapeutic targets. Your responsibilities will include: Designing, performing, and interpreting mechanistic experiments, including in vivo animal studies; Establishing and adapting experimental approaches as required; Analyzing and presenting scientific data; Developing collaborative projects; Mentoring PhD and MSc students; Contributing to manuscripts, scientific meetings, and grant applications. Experimental approaches in our group include in vivo leukemia and allogeneic hematopoietic stem cell transplantation models, liquid chromatography-mass spectrometry metabolomics and lipidomics, functional genomics and CRISPR screens, spectral flow cytometry, cell sorting, bulk, single-cell and spatial transcriptomics, and functional immune and metabolic assays. Your profile We are looking for an experimental scientist with strong intellectual curiosity, knowledge and practical expertise in tumor immnology, and an interest in mechanistic cancer research. Applicants should have: A PhD (or equivalent degree) in cancer biology, immunology, molecular biology, hematology, or a related discipline; A strong conceptual and experimental background in tumor biology and/or immunology; Substantial hands-on experience with in vivo mouse tumor models, ideally in hematological cancers, and willingness to perform animal experiments; Extensive experience with (spectral) flow cytometry and molecular biology; A strong experimental track record, ideally including a high-quality first-author publication; The ability to independently design, execute, and interpret mechanistic experiments; Excellent communication skills (in English) and the ability to work collaboratively in an interdisciplinary team. Experience in leukemia research, tumor immunology, metabolism, CRISPR screening, or histology is an advantage but not required. We are particularly interested in candidates who want to take intellectual ownership of an ambitious project, pursue mechanistic questions, and develop their own scientific profile at the interface of tumor immunology and metabolism. Apply Now Don't forget to mention EuroScienceJobs when applying.