Postdoc: Metabolic TME in Pediatric Neuroblastoma

ETH Zürich; Schwerzenbach; On-site; CHF 110,000 - 130,000; Full time

Job summary

ETH Zürich seeks a postdoctoral researcher to study metabolic determinants of the pediatric tumor microenvironment, focusing on neuroblastoma. You will establish mouse models, analyze vascular-immune interactions, and collaborate across two labs and the NCCR consortium.

The role requires experience in cancer metabolism, vascular biology, immunometabolism, and proficiency in English. It offers ETH Zurich resources, cross-institution mentorship, and a competitive salary.

Qualifications

• PhD in cancer biology, vascular biology, immunometabolism or a related field.
• Strong research background in cancer metabolism, vascular biology, or immune metabolism.
• Hands-on experience with mouse models of cancer.
• Familiarity with cellular and molecular techniques relevant to tumor biology (e.g. imaging, flow cytometry, transcriptomics).
• Strong communication skills and ability to collaborate across two labs and a consortium.
• Advanced proficiency in English.

Responsibilities

• Establish and characterize novel genetic and/or orthotopic mouse models of neuroblastoma.
• Investigate how neuroblastoma rewires the metabolic tumor microenvironment, especially vascular and immune‑metabolic crosstalk.
• Characterize tumor vascular diversity, organization and metabolic gradients, relation to hypoxia and nutrient delivery.
• Profile the immune TME and its interaction with tumor vasculature using single‑cell/spatial transcriptomics and metabolomics.
• Test interventions targeting the immune‑vascular interface to identify metabolic vulnerabilities.
• Collaborate with other NCCR workpackages to integrate metabolic, vascular and immune data.
• Contribute to manuscript preparation and data reporting within the consortium.

Skills

Mouse models

Cancer metabolism

Vascular biology

Immunometabolism

Education

PhD in cancer biology or related field

Tools

Imaging

Flow cytometry

Single-cell transcriptomics

Job description

ETH Zürich seeks a postdoctoral researcher to study metabolic determinants of the pediatric tumor microenvironment, focusing on neuroblastoma. You will establish mouse models, analyze vascular-immune interactions, and collaborate across two labs and the NCCR consortium.

The role requires experience in cancer metabolism, vascular biology, immunometabolism, and proficiency in English. It offers ETH Zurich resources, cross-institution mentorship, and a competitive salary.