PhD position on "On-Chip Separation of Proteins for Single-Cell Proteome Profiling"

Institute for Biomedical Engineering (D-ITET); Zürich; Vor Ort; CHF 40’000 - 60’000; Vollzeit

Zusammenfassung

A leading research institute in Zürich offers a PhD position focused on the development of technologies for protein detection and analysis. Candidates will engage in innovative research, collaborating across disciplines, and have opportunities for student supervision and contributions to scientific publications.

Qualifikationen

• Solid knowledge in on-chip protein separation, microfluidics or nanofluidic.
• Hands-on experience with protein samples.
• Familiarity with bioinformatic data analysis tools.

Aufgaben

• Develop a platform for protein detection in single cells.
• Optimize scanning nanopore microscope for protein detection.
• Collaborate on data analysis with machine learning colleagues.

Kenntnisse

Protein separation knowledge

Microfluidics

Data analysis

Ausbildung

PhD in relevant field

Jobbeschreibung

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PhD position on "On-Chip Separation of Proteins for Single-Cell Proteome Profiling", Zürich

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Client:

Institute for Biomedical Engineering (D-ITET)

Location:

Job Category:

Other

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Job Reference:

7a20559c3d4b

Job Views:

3

Posted:

27.06.2025

Expiry Date:

11.08.2025

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Job Description:

• You will be developing a platform for the detection of protein production and secretion in single cells. An example of application is to study antibody secretion in immune cells upon their activation
• You will be optimizing recently established scanning nanopore microscope for specific detection of proteins in complex physiological solutions, addressing these open research challenges:
• Specificity of the sensor towards selected proteins: Enhancing the contrast for specific proteins
• Data analysis: Improving data analysis approaches for capturing more information from each individual protein
• Sampling from single cells: Developing methods for better sampling from individual cells, and handling of small volume samples
• You will be collaborating with colleagues from the machine learning domain to improve data analysis
• You will be responsible for project meetings, reporting, scientific publications, and conference/seminar presentations
• You will supervise master/bachelor students

Profile

Successful candidates should have

• Solid working knowledge in either on-chip protein separation, microfluidics or nanofluidic.
• Hands-on experience with protein samples.
• Working experience in cell labs is valuable.
• Familiarity with data analysis using bioinformatic tools is highly valuable.
• Independent personality, self-driven, creative, solution-oriented, open-minded, team-player & collaborative.