PhD in Translational Immunology: EBV-TCR Discovery

Euraxess; Basel; Vor Ort; CHF 50.000 - 60.000; Vollzeit

Benefits dieser Stelle

Fully funded PhD position

State-of-the-art facilities

Collaborative international & clinical

Zusammenfassung

University of Basel invites applications for a fully funded PhD position in Infection Biology within the DBM. The project focuses on T-cell immunity in EBV-associated cancers, combining patient-derived tumor models with cutting-edge technologies including CRISPR/Cas9, immunopeptidomics, and single-cell multiomics.

Close supervision and collaboration with clinicians and GMP facilities are offered. Join an interdisciplinary team with opportunities to publish in high-impact journals and present at

Qualifikationen

• Master's degree in Immunology, Molecular Biology, or a related discipline.
• Strong interest in cancer and infection immunology and translational research.
• Hands-on laboratory experience in cell culture and immune assays.
• Excellent organizational skills and attention to detail.
• Strong analytical thinking and willingness to learn new techniques.
• Good written and spoken English.
• Multiparameter flow cytometry, immune phenotyping.
• Single-cell sequencing technologies or immunopeptidomics.
• Transcriptomic or genomic data analysis (R/Python).
• A fully funded PhD position within an ambitious and collaborative research environment.
• Access to state-of-the-art research infrastructure.

Aufgaben

• Establish patient-derived in vitro tumor models from EBV-positive malignancies.
• Isolate and characterize tumor-infiltrating lymphocytes (TILs) from patient samples.
• Perform single-cell profiling of immune cell transcriptomes and TCR repertoires.
• Reconstruct and validate candidate TCRs to determine antigen specificity, HLA restriction, and anti-tumor activity.
• Perform advanced immunological assays including multicolor flow cytometry, T-cell expansion, cytokine secretion, proliferation, and cytotoxicity assays.
• Integrate functional, genomic, and transcriptomic datasets in collaboration with computational scientists.
• Present research findings at laboratory meetings and international conferences.
• Contribute to high-impact publications and collaborative research projects.

Kenntnisse

Flow cytometry

Single-cell sequencing

Immunology

Molecular biology

Cell culture

R/Python

Data analysis

English communication

Ausbildung

Master's degree in Immunology or related field

Tools

CRISPR/Cas9 genome engineering

Immunopeptidomics instrumentation

Transcriptomics tools

Jobbeschreibung

University of Basel invites applications for a fully funded PhD position in Infection Biology within the DBM. The project focuses on T-cell immunity in EBV-associated cancers, combining patient-derived tumor models with cutting-edge technologies including CRISPR/Cas9, immunopeptidomics, and single-cell multiomics.

Close supervision and collaboration with clinicians and GMP facilities are offered. Join an interdisciplinary team with opportunities to publish in high-impact journals and present at