Fully Funded PhD — Translational Immunology & TCR Discovery

EURAXESS Ireland; Basel; Vor Ort; CHF 45.000 - 52.000; Vollzeit

Benefits dieser Stelle

Fully funded PhD position

Zusammenfassung

University of Basel invites applications for a fully funded PhD position in Infection Biology focusing on T-cell immunity in EBV-associated cancers. You will develop patient-derived tumor models and apply cutting-edge technologies such as CRISPR/Cas9, single-cell multiomics, and TCR discovery in a translational research setting.

The project is embedded in a collaborative environment with clinicians, GMP facilities, and clinical trial units, offering training and opportunities to publish in

Qualifikationen

• Master's degree in Immunology or related field.

Aufgaben

• Establish patient-derived in vitro tumor models from EBV-positive malignancies.
• Isolate and characterize tumor-infiltrating lymphocytes (TILs) from patient samples.
• Perform single-cell profiling of immune cell transcriptomes and TCR repertoires.
• Reconstruct and validate candidate TCRs to determine antigen specificity, HLA restriction, and anti-tumor activity.
• Perform advanced immunological assays including multicolor flow cytometry, T-cell expansion, cytokine secretion, proliferation, and cytotoxicity assays.
• Integrate functional, genomic, and transcriptomic datasets in collaboration with computational scientists.
• Present research findings at laboratory meetings and international conferences.
• Contribute to high-impact publications and collaborative research projects.

Kenntnisse

Flow cytometry

Single-cell sequencing

Immunopeptidomics

R/Python

Cell culture

Molecular biology

Immune assays

Immunology background

CRISPR/Cas9

Ausbildung

Master's degree in Immunology / related field

Tools

CRISPR/Cas9

Single-cell sequencing platforms

Jobbeschreibung

University of Basel invites applications for a fully funded PhD position in Infection Biology focusing on T-cell immunity in EBV-associated cancers. You will develop patient-derived tumor models and apply cutting-edge technologies such as CRISPR/Cas9, single-cell multiomics, and TCR discovery in a translational research setting.

The project is embedded in a collaborative environment with clinicians, GMP facilities, and clinical trial units, offering training and opportunities to publish in