Hybrid PBPK Lead Scientist to Associate Director

C028 (FCRS = CH028) Novartis Pharma AG; Basel; Hybrid; CHF 123.000 - 228.000; Vollzeit

Benefits dieser Stelle

Hybrid work model

Long-term equity awards

Parental leave

Zusammenfassung

Novartis Pharma AG in Basel, Switzerland, seeks a Senior Principal Scientist or Associate Director level modeler to advance translational PBPK modeling across disease areas. The role focuses on integrating in vitro/in vivo data for DDI, absorption, and PK predictions, supporting regulatory submissions with high attention to regulatory guidance.

The position requires deep ADME/DMPK knowledge, PBPK tools (PK-Sim, Simcyp, GastroPlus) and other modeling software (Monolix, R, Phoenix, Nonmem).

Qualifikationen

• PhD in pharmaceutical sciences or related discipline with experience in ADME/DMPK sciences, biopharmaceutics, and modeling and simulation.
• At least 5+ years in pharmaceutical industry including demonstrated knowledge and experience with PBPK modeling.
• Hands on experience with PBPK modeling tools such as PK-Sim, Simcyp, or GastroPlus is required.
• Experience with modeling software such as Monolix, R, Phoenix, or Nonmem is desired.
• Experience in authoring regulatory documents, knowledge of global regulatory requirements and guidance.

Aufgaben

• Expert PBPK modeler to provide translational modeling support for global drug discovery and development projects.
• Perform translational PBPK analyses to predict clinical drug exposure in specific populations, assess potential for DDI, understand clinical impact of disease on drug exposure, as well as apply biopharmaceutic PBPK modeling to support formulation changes and achieve clinical biowaivers.
• Integrate PK/ PD data, ADME and DDI findings.
• Ability to interpret and communicate modeling results and potential impact to project teams.
• Prepare summary documents for use in regulatory submissions and ability to respond independently to health authority questions.

Jobbeschreibung

Novartis Pharma AG in Basel, Switzerland, seeks a Senior Principal Scientist or Associate Director level modeler to advance translational PBPK modeling across disease areas. The role focuses on integrating in vitro/in vivo data for DDI, absorption, and PK predictions, supporting regulatory submissions with high attention to regulatory guidance.

The position requires deep ADME/DMPK knowledge, PBPK tools (PK-Sim, Simcyp, GastroPlus) and other modeling software (Monolix, R, Phoenix, Nonmem).