Director, Targeted Protein Degradation Biology

Ridgeline Discovery; Basel; Vor Ort; CHF 180.000 - 260.000; Vollzeit

Benefits dieser Stelle

Prime Location

Commuter Benefits

Flexible Working

Christmas Closure

Birthday Day Off

Lunch & Food

Coffee & Connection

Learning & Development

Innovation & Creativity

Our People

Zusammenfassung

SERAC Biosciences AG in Basel seeks an Associate Director / Director, Biology in Targeted Protein Degradation to drive degrader programs from target validation through IND-enabling translational work. You will provide science and program leadership across discovery biology, translational pharmacology, biomarker strategy and pre-IND package preparation.

You will build and mentor a team of scientists, lead cross-functional collaboration with chemistry, DMPK and toxicology, and ensure high-quality

Qualifikationen

• PhD in Cancer Biology, Immunology, Molecular/Cell Biology, Biochemistry, Pharmacology, or related field.
• 8–12+ years of industry experience in biotech/pharma with a track record in degrader programs.
• Experience leading cross-functional teams and CROs, with strong communication skills.

Aufgaben

• Lead degrader programs from target identification through IND-enabling pharmacology and translational packages.
• Define and execute integrated biology and translational plans for lead identification, dose rationale, and FIH study design.
• Oversee ex vivo / in vivo efficacy and PD studies, integrating PK/PD/degradation readouts.
• Collaborate with DMPK and toxicology for PK/PD–degradation integration and safe IND-ready designs.
• Develop biomarker strategies that capture degradation and link to efficacy and safety in preclinical/early clinical studies.
• Design MoA and degradation pharmacology strategies to support go/no-go decisions and translation.
• Lead cell-based and biochemical assays for induced-proximity modalities and evaluate E3 ligases.

Kenntnisse

TPD biology

PROTACs

Molecular glue degraders

In vivo PK/PD

Cross-functional leadership

E3 ligase biology

Degrader pharmacology

Ausbildung

PhD in Cancer Biology/Immunology/Biochem/Pharmacology

Jobbeschreibung

SERAC Biosciences AG in Basel seeks an Associate Director / Director, Biology in Targeted Protein Degradation to drive degrader programs from target validation through IND-enabling translational work. You will provide science and program leadership across discovery biology, translational pharmacology, biomarker strategy and pre-IND package preparation.

You will build and mentor a team of scientists, lead cross-functional collaboration with chemistry, DMPK and toxicology, and ensure high-quality