Director, Clinical Pharmacology & PK-PD Strategy (Hybrid)

CSL; Zürich; Hybrid; CHF 197,000 - 225,000; Full time

Job summary

CSL is seeking a Director of Clinical Pharmacology to provide expert leadership in PK-PD across diverse programs within the R&D portfolio. The role involves guiding pharmacokinetic/pharmacodynamic assessments and driving modeling and simulation to support decision-making throughout clinical development.

The successful candidate will work independently with cross-functional teams, shaping development plans, and representing pharmacology in regulatory interactions to support registration of

Qualifications

• PhD or PharmD in Clinical Pharmacology or related field.
• Experience with PK-PD strategy and regulatory submissions is required.
• Minimum 8 years in industry contributing to clinical pharmacology in drug development.

Responsibilities

• Lead clinical pharmacology and PK-PD strategies for multiple programs.
• Oversee design of clinical pharmacology studies and protocol sections.
• Perform PK/PD analyses and inform dose selection.
• Interpret study results and prepare reports and publications.
• Collaborate across clinical development, translational science, biostatistics, and other functions.
• Apply modeling and simulation to guide development decisions.
• Support regulatory submissions and responses to health authorities.

Skills

Clinical pharmacology

Pharmacokinetics

Pharmacodynamics

PK-PD strategy

Pharmacometric modeling

Modeling & simulation

Regulatory submissions

Education

PhD in Clinical Pharmacology

PharmD in Pharmacology

Clinical pharmacology fellowship

Tools

Pharmacometric software

Job description

CSL is seeking a Director of Clinical Pharmacology to provide expert leadership in PK-PD across diverse programs within the R&D portfolio. The role involves guiding pharmacokinetic/pharmacodynamic assessments and driving modeling and simulation to support decision-making throughout clinical development.

The successful candidate will work independently with cross-functional teams, shaping development plans, and representing pharmacology in regulatory interactions to support registration of