Cryogenic Electron Microscopist Support

EPFL - Swiss Federal Institute of Technology Lausanne; Vaud; On-site; CHF 110,000 - 140,000; Full time

Job summary

EPFL in Lausanne invites a Cryogenic Electron Microscopist to join the Dubochet Center for Imaging (DCI). You will operate, maintain and troubleshoot high-end cryo-EM instruments, including Glacios and Titan Krios, and support researchers from EPFL, UNIL and external clients.

You will prepare samples, acquire data for SPA and cryo-ET, process images, help interpret structures, and contribute to platform development while delivering reliable, user-focused service in a fast-paced, collaborative

Qualifications

• Ph.D. in structural biology or related field with cryo-EM experience.
• At least one year of hands-on cryo-EM experience covering operation, support, and data handling.
• Experience with cryo-EM software cryoSPARC, IMOD/eTomo, and Scipion.
• Experience with SPA and/or cryo-ET workflows desirable.
• Excellent communication in English; strong motivation to explore new domains.

Responsibilities

• Cryo-EM sample preparation and data acquisition for SPA and cryo-ET.
• Operate and maintain Glacios and Titan Krios instruments; troubleshoot issues.
• Perform on-the-fly and offline data processing and image analysis.
• Contribute to development of the DCI cryo-EM platform and ensure high service levels.
• Advise researchers from EPFL, UNIL and external customers across project stages.

Skills

Cryo-EM operation

Data acquisition

Data processing

Communication in English

Team collaboration

Education

Ph.D. in Structural Biology

Tools

cryoSPARC

IMOD/eTomo

Scipion

Job description

Cryogenic Electron Microscopist Support

EPFL - Swiss Federal Institute of Technology Lausanne

Lausanne, Switzerland

Mission

The Cryogenic Electron Microscopist will be responsible for the operation, maintenance and troubleshooting of specialized scientific equipment, including one Glacios and three Titan Krios microscopes, within the cryo-EM core facility of the Dubochet Center for Imaging (DCI).

Main duties and responsibilities

As part of the DCI team, your responsibilities will include:

• Cryo-EM sample preparation
• Data acquisition for single-particle analysis (SPA) and cryo-electron tomography (cryo-ET)
• On-the-fly and offline data processing, advanced image processing
• Structure determination and interpretation

As a cryo-EM support, you will provide technical and scientific support to researchers from EPFL, UNIL as well as external customers, advising users throughout the different stages of their projects, from experimental planning and data acquisition to image processing and structure determination. You will also contribute to the continuous development and improvement of the DCI cryo-EM platform, helping to ensure a high level of service, reliability and performance for its users.

Profile

Ph.D. in tructural biology or related field with experience in Cryo-EM

At least one year of hands-on experience in cryo-EM, including instrument operation, facility support, training, data acquisition, data processing and/or cryo-ET

Experience with cryo-EM image-processing software such as cryoSPARC, IMOD/eTomo, and Scipion

Experience with SPA and/or cryo-ET workflows is desirable

Good understanding of cryo-EM data acquisition and processing workflows

Excellent communication skills in an English-speaking environment

Strong motivation to explore new research domains

We are looking for a person who is:

• Service-oriented, proactive, and enthusiastic
• Practical and hands-on, with the flexibility to thrive in a dynamic, service-oriented platform
• Comfortable with change and able to adapt quickly to evolving priorities and workflows
• Reliable and committed to delivering high-quality results for all types of users and customers
• Collaborative, with clear communication skills and a constructive team spirit
• Able to work independently while contributing effectively to a team environment