Chief Medical Officer

SJP Biotec GmbH; Zürich; Hybrid; CHF 260.000 - 420.000; Vollzeit

Zusammenfassung

SJP Biotec GmbH in Zürich is actively seeking a Chief Medical Officer to lead clinical development strategy for multiple indications and to act as the clinical face of the company. You will drive trial design, regulatory submissions, and biomarker-driven programs across global sites.

The ideal candidate has 10+ years in oncology clinical development with strong FDA/EMA interactions and a track record in breast cancer, NSCLC, or KRAS biology, complemented by publication/presentation excellence.

Qualifikationen

• MD with specialization in medical oncology and hematology.
• 10+ years in oncology clinical development with trial leadership.
• Proven IND/CTA submissions track record.
• Experience interacting with FDA and EMA.
• Biomarker-driven trial design expertise.
• Experience in breast cancer, NSCLC, and KRAS biology.
• Strong publication/congress presentation record.
• Excellent presentation and teamwork abilities.

Aufgaben

• Translate board directives and serve as the clinical face of the company.
• Lead clinical development across the SJP portfolio.
• Design Phase 2/3 protocols and oversee CTA/IND submissions.
• Develop biomarker-driven patient selection strategies.
• Build relationships with academic and clinical sites across regions.
• Lead regulatory strategy for accelerated pathways when applicable.

Kenntnisse

Clinical development leadership

IND/CTA submissions

Biomarker-driven trial design

Regulatory strategy

Stakeholder management

Team leadership

Scientific communication

Ausbildung

MD, oncology/hematology specialization

Jobbeschreibung

Chief Medical Officer

SJP Biotec GmbH Vacant since : 01.09.2026 Number of jobs : 1 8001 Zürich (ZH) 100% Immediately Permanent

SJP Biotec GmbH is a clinical-stage precision oncology company pioneering a first-in-class Selective Translation Regulatory Inhibitor (STRI) platform powered to overcome treatment resistance in refractory cancers. Founded in 2024, SJP targets RAS-driven, hormone-receptor-positive, and immune-refractory tumors with a novel pipeline of small molecules developed in our lab and ready to proceed with regulatory-grade trials.Backed by a Scientific Advisory Board that includes world-leading authorities in RAS and breast cancer biology, and immuno-oncology, SJP has established clinical partnerships with leading medical centers world-wide including UCSF, NCI, MD Anderson, Baylor College of Medicine, MSKCC, and McGill, to name a few.

The OpportunityThis is a stimulating and unique opportunity to join a scientifically exceptional, capital-efficient biotech company doing groundbreaking work at a pivotal inflection point. The CMO/SVP of Clinical Development will serve as the company's most senior clinical leader, responsible for designing and executing a multi-indication clinical development strategy across one of the most compelling areas in the current oncology drug development field - RAS/eIF4A/translation-pathway inhibition.

Key Responsibilities- Translate and deliver key directives from the board and senior management, and serve as the clinical face of the company.- Lead and manage all clinical development activities across the SJP portfolio- Design Phase 2 and 3 clinical protocols and oversee CTA/IND submissions to BfArM, FDA, and EMA- Develop and implement biomarker-driven patient selection strategies- Build and manage relationships with leading academic and clinical sites across Germany, the EU, and the US- Oversee Investigator Initiated Trials and partnerships, providing scientific leadership and interactions as required- Lead regulatory strategy, developing approaches for Fast Track Designation, Breakthrough Therapy Designation, and accelerated approval pathways as applicable- Support pharmaceutical partnering activities - prepare clinical data packages and respond to due diligence for potential licensing and out-licensing transactions- Build out of the clinical development and operations function, including recruitment of CRAs, medical monitors, and data management staff- Present clinical data at major oncology congresses and to key opinion leaders- Interact with potential investors and financial institutions to raise capital when needed.

Candidate ProfileEssential Qualifications- MD, with specialization in medical oncology and hematology- 10+ years of experience in oncology clinical development within pharma, biotech, or CRO settings with hands-on clinical trial leadership- Demonstrated track record of successful IND/CTA submissions- Leadership of interactions with FDA and/or EMA- Experience with biomarker-driven trial design and companion diagnostic development- Expertise in breast cancer, NSCLC, and KRAS-mutant tumor biology- Strong understanding of the competitive treatment landscape in clinical oncology- Proven ability to manage investigator-initiated trials and academic site partnerships- Strong scientific publication and/or congress presentation record in clinical oncology- Excellent presentation skills- Emphasizing teamwork and leading a team of experts in their fields

Highly Desired (But not required)- Experience with RAS/KRAS biology, MAPK pathway inhibitors, or translation-pathway therapeutics- PhD in an associated area of cancer biology- Experience with basket trial design and multi-cohort oncology studies- Background in immuno-oncology combinations, particularly in checkpoint inhibitor resistance settings- Prior involvement in pharma partnering or licensing due diligence from the biotech side- Working knowledge of German regulatory frameworks alongside international GCP/ICH guidelines- Established professional network at leading cancer centres

• Work location 8001 Zürich (ZH)
• Additional information on the place of work Home Office
• Workload 100%
• Employment start Immediately
• Employment duration Permanent

• By email [e-mail]