Sr. Principal Scientist - Discovery Radiochemistry

Eli Lilly and Company; Ontario; On-site; CAD 80,000 - 100,000; Full time

Job summary

A leading healthcare company is seeking a skilled radiochemist to develop and support radiolabeling processes for preclinical experiments. The role involves collaboration with teams and partners, ensuring the supply of radiolabeled compounds. Candidates should have a strong background in chemistry and experience in radiochemistry, with the ability to manage projects effectively in a fast-paced environment.

Qualifications

• 5+ years of radiochemistry experience or a PhD in relevant fields.
• Ability to work independently in a fast-paced environment.

Responsibilities

• Develop radiochemistry processes and formulations.
• Produce and supply radiolabeled compound batches for preclinical evaluation.
• Train colleagues on radiochemistry processes.

Skills

Organizational Skills

Communication Skills

Project Prioritization

Education

BS/MS in Organic Chemistry

PhD in Organic, Inorganic, or Radiochemistry

Tools

radio-HPLC-MS

radio-ITLC

Automated Radiosynthesizers

Job description

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees worldwide work to discover and bring life-changing medicines to those in need, improve disease understanding and management, and contribute to our communities through philanthropy and volunteerism. We are committed to our work and prioritize people. We seek individuals determined to improve lives globally.

For over 140 years, Lilly has dedicated itself to discovering medicines that enhance life. Our research laboratories are where our scientists develop new medicines to address the world’s greatest health challenges.

Position Summary :

The successful candidate will support our discovery program by developing therapeutic and diagnostic radiolabeling processes and ensuring the supply of materials. They will collaborate with internal teams and external partners to enable the supply of radiolabeled compounds for preclinical experiments.

Responsibilities :

1. Develop radiochemistry processes and formulations.
2. Create analytical testing methods to characterize research batches.
3. Produce, test, and supply radiolabeled compound batches for preclinical evaluation.
4. Transfer radiochemistry and testing methods to team members and external partners.
5. Train colleagues and partners on radiochemistry processes and provide technical support as needed.
6. Prepare and deliver presentations for meetings.
7. Document laboratory activities, develop reports, manuscripts, and patent applications.
8. Perform other duties as assigned.

Basic Requirements :

• BS/MS in organic chemistry, chemistry, or related field with 5+ years of radiochemistry experience, or a PhD in organic, inorganic, or radiochemistry.
• Ability to work independently with strong organizational and communication skills.
• Proven project prioritization and timeline management in a fast-paced environment.

Additional Preferences :

• Experience in a radiochemistry environment.
• Hands-on experience with imaging radioisotopes (e.g., F-18, Ga-68, Cu-64) and/or therapeutic radioisotopes (e.g., Lu-177, Ac-225).
• Experience with quality control testing of radiolabeled compounds (radio-HPLC-MS, radio-ITLC).
• Knowledge of environmental health and radioprotection standards.
• Familiarity with automated radiosynthesizers.
• Understanding of GMPs and relevant regulatory guidelines.

Physical Demands / Travel :

• Up to 20% travel domestically and internationally; valid passport required.
• Ability to lift up to 30 kg.
• Use of safety shoes and protective equipment in the lab environment.
• This role requires onsite work during the workweek.