Research Technician II

Uhnresearch; Toronto; On-site; CAD 70,000 - 90,000; Full time

Job summary

A leading healthcare research institution is seeking a bioanalytical chemist to join their collaborative drug discovery team. The role involves developing LC-MS methods and performing bioanalytical assays to support drug development. Candidates should have a strong background in chemistry or biochemistry and experience in method validation. This position offers a competitive salary and benefits within a supportive work environment.

Benefits

Competitive offer packages

Healthcare of Ontario Pension Plan (HOOPP)

Close access to Transit

Flexible work environment

Opportunities for development and promotions

Corporate discounts (travel, restaurants, etc.)

Qualifications

• 3+ years experience in bioanalytical method development.
• Extensive experience in quantifying small molecules in biological fluids.

Responsibilities

• Design and optimize LC-MS bioassays for small molecule quantification.
• Perform routine analysis of samples from PK experiments.

Skills

Analytical Skills

Problem Solving

Communication

Time Management

Education

Bachelor’s degree

Master’s degree

Tools

LC-MS

NMR

Job description

UHN is Canada’s #1 hospital and the world’s #1 publicly funded hospital. With 10 sites and more than 44,000 TeamUHN members, UHN consists of Toronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre, Toronto Rehabilitation Institute, The Michener Institute of Education and West Park Healthcare Centre. As Canada's top research hospital, the scope of biomedical research and complexity of cases at UHN have made it a national and international source for discovery, education and patient care. UHN has the largest hospital-based research program in Canada, with major research in neurosciences, cardiology, transplantation, oncology, surgical innovation, infectious diseases, genomic medicine and rehabilitation medicine. UHN is a research hospital affiliated with the University of Toronto.

UHN’s vision is to build A Healthier World and it’s only because of the talented and dedicated people who work here that we are continually bringing that vision closer to reality.

Site:Krembil Research Institute
Department:University Health Network - Collaborative Centre for Drug Discovery and Therapeutics
Reports to:Dr. Mark Reed, Co-Lead, Collaborative Centre for Drug Discovery and Therapeutics, and Director UHN Therapeutics
Work Model: On-site
Hours:37.5 hours per week
Shifts: Day
Status:Temporary Full-Time
Closing Date: June 6, 2025

Position Summary:

We are seeking a highly motivated and experienced bioanalytical chemist to join a highly collaborative, multi-disciplinary team of drug discovery scientists. The successful candidate will perform LCMS method development and routine bioanalytical assays to support in vitro ADME screening and in vivo PK/TK studies.

Duties & Responsibilities:

• Design, develop and optimize LC-MS bioassays for the quantification of a range of small molecule compounds in biological matrices.
• Perform routine analysis of samples deriving from AMDE or PK experiments in buffer and tissue.
• Apply strong analytical/problem solving skills to troubleshoot LC-MS methods.
• Operate general laboratory equipment and instrumentation systems and utilize automated data collection and processing programs.
• Perform calibration, maintenance and troubleshooting of LCMS instruments.
• Coordinate repairs and service appointment with instrument vendors.
• Document experiment details, calculations, results and observations.
• Communicate assay needs, timelines, progress updates and bioanalytical assay deliverables to project team members.
• Collaborate with team members from multiple functional areas to support project development.
• Participate in the preparation, review, and revision of laboratory standard operating procedures.
• Perform additional related duties, as assigned

Qualifications

Qualifications:

• Bachelor’s degree with 3+ years experience or master’s degree in chemistry, biochemistry, biology or a related field.
• Extensive experience in LC-MS bioanalytical method development and validation for quantifying small molecules in biological fluids and tissues using various techniques.
• Hands-on experience in various biological sample preparation techniques such as PP, LLE, and SPE.
• NMR experience an asset.
• Demonstrated knowledge and troubleshooting skills on LC separation techniques (i.e. RP, NP, HILIC) with multiple detectors including UV-visible, PDA, DAD and mass spectrometers.
• Proficiency with various data acquisition and processing programs.
• Proven ability to work independently and to collaborate cross-functionally to accomplish goals in a timely manner.
• Strong analytical and problem-solving skills.
• Demonstrated advanced time management and multi-tasking abilities
• Excellent interpersonal, communication, organization and computer skills.

Additional Information

In addition to working alongside some of the most talented and inspiring healthcare professionals in the world, UHN offers a wide range of benefits, programs and perks. It is the comprehensiveness of these offerings that makes it a differentiating factor, allowing you to find value where it matters most to you, now and throughout your career at UHN.

• Competitive offer packages
• Government organization and a member of the Healthcare of Ontario Pension Plan (HOOPP https://hoopp.com/ )
• Close access to Transit and UHN shuttle service
• A flexible work environment
• Opportunities for development and promotions within a large organization
• Additional perks (multiple corporate discounts including: travel, restaurants, parking, phone plans, auto insurance discounts, on-site gyms, etc.)

Current UHN employees must have successfully completed their probationary period, have a good employee record along with satisfactory attendance in accordance with UHN's attendance management program, to be eligible for consideration.

All applications must be submitted before the posting close date.

UHN uses email to communicate with selected candidates. Please ensure you check your email regularly.

Please be advised that a Criminal Record Check may be required of the successful candidate. Should it be determined that any information provided by a candidate be misleading, inaccurate or incorrect, UHN reserves the right to discontinue with the consideration of their application.

UHN is an equal opportunity employer committed to an inclusive recruitment process and workplace. Requests for accommodation can be made at any stage of the recruitment process. Applicants need to make their requirements known.

We thank all applicants for their interest, however, only those selected for further consideration will be contacted.