Senior Scientist, Capsid Engineering

Roche Holdings Inc.; Chelmsford; On-site; USD 103,000 - 192,000; Full time

Job summary

An innovative firm is seeking a Senior Scientist in Capsid Engineering to join their Discovery Research Team. This exciting role involves developing cutting-edge gene delivery platforms, focusing on creating novel AAV capsids that enhance transduction capabilities. You will collaborate with diverse teams, implement high-throughput screening strategies, and contribute to groundbreaking research that aims to translate findings into clinical applications. If you are passionate about advancing healthcare solutions and eager to make a significant impact, this opportunity is perfect for you.

Qualifications

• 3-5 years of relevant experience in biological research.
• Hands-on experience with high complexity library preparations.

Responsibilities

• Develop experimental strategies for novel capsid engineering.
• Conduct in vitro studies in preclinical animal models.

Skills

Library Preparation

Bioinformatics

Molecular Cloning

Cell Culture

ELISA

Gene Therapy

Analytical Skills

Problem-Solving Skills

Education

PhD in Biological Discipline

Tools

NGS Software

Bio/Pharma Software Tools

Job description

At Roche, you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted, and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop, and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.

The Position

We are seeking a Senior Scientist in Capsid Engineering to be a key member of the Discovery Research Team. You will participate in developing Spark's gene delivery platforms, focusing on creating novel AAV capsids with enhanced properties, particularly the ability to transduce specific cell types. Discovering such capsids will facilitate the translation from in vitro to in vivo proof of concept and ultimately clinical application.

The Opportunity:

1. Ideate experimental strategies to engineer novel capsids with enhanced properties for clinical translation.

2. Develop and implement high-throughput capsid library screening strategies to discover improved variants.

3. Support approaches that enable the isolation of AAV capsid variants capable of transducing specific cell types in rodents and NHPs.

4. Collaborate with NGS and machine learning groups to enhance directed evolution for isolating AAVs with tailored properties.

5. Design and conduct in vitro studies in preclinical animal models of genetic diseases in collaboration with other Discovery and Gene Therapy scientists.

6. Support joint programs and collaborations with external partners.

7. Write study reports, manuscripts, and present results at scientific meetings.

Who You Are:

1. PhD in a biological discipline with 3-5 years of relevant experience.

2. Hands-on experience with high complexity library preparations.

3. Familiarity with NGS and bioinformatics is required.

4. Proficiency in lab techniques such as plasmid design, molecular cloning, qPCR, cell culture, ELISA, luciferase assays, SDS-PAGE/Western blotting, etc.

5. Experience with AAV gene therapy is required.

6. Willingness to travel occasionally for short periods.

Preferred Qualifications:

• Experience with laboratory animal studies is preferred.

• Strong analytical and problem-solving skills.

• Familiarity with bio/pharma software tools.

• Strong publication record is a plus.

• Experience managing external collaborations is a plus.

The expected salary range for this position in Philadelphia is $103,400 to $192,000. Actual pay will be determined based on experience, qualifications, location, and other factors permitted by law.

This position qualifies for benefits, details of which are available through the provided link.

Benefits

We are a global team of over 100,000 employees dedicated to advancing science and healthcare. Our efforts have resulted in millions of treatments and tests worldwide. We foster a culture of exploration, creativity, and high ambition to deliver healthcare solutions that make a global impact.

Let's build a healthier future, together.

Roche is an equal opportunity employer. We promote merit, qualifications, and competence in employment practices and prohibit unlawful discrimination based on protected statuses. If you need accommodations during the application process, please contact us through the provided form.