Scientist, Biomolecular Interactions (12 Month Contract)

Amgen; Burnaby; On-site; CAD 109,000 - 148,000; Full time

Job summary

Amgen in Burnaby, BC is seeking a Scientist, Biomolecular Interactions on a 12-month contract to join the In Vitro Pharmacology group and discover novel therapeutic antibodies. You will design and perform high-throughput and targeted biophysical screening assays to rank discovery programs and later-stage candidates.

The role requires strong laboratory skills, data analysis using PRISM and Python, and collaboration with a team of scientists to develop and implement assays with guidance from the

Qualifications

• Doctorate degree or equivalent.
• Master’s degree +3 years related experience or
• Bachelor’s degree +5 years related experience.

Responsibilities

• Conduct routine and novel affinity/kinetic characterization screens on platforms (Carterra, Octet, Biacore, KinExA).
• Instrument housekeeping, reagent ordering, troubleshooting.
• Data summarizing and reporting (ELN, Screener, Benchling, slide decks).

Skills

Affinity Kinetics

Lab skills

Data analysis

DoE experience

Education

Doctorate degree

Master's degree with 3 years experience

Bachelor's degree with 5 years experience

Tools

Biacore

KinExA

Carterra

Octet

Benchling

ELN

PRISM

Job description

Career Category

Scientific

Job Description

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Role: Scientist, Biomolecular Interactions (12 Month Contract)

Reports to: Principal Scientist

Location: Burnaby, BC

What you will do

Let’s do this. Let’s change the world. In this vital role, you will join Amgen BC’s affinity team in In Vitro Pharmacology group to discover novel therapeutic antibodies.

Our small team specializes in designing and conducting both high throughput and smaller, custom biophysical screening assays to rank and characterize both discovery and later stage large molecule therapeutic programs. The individual will join a team of dedicated scientists to discover and characterize molecules that have the potential to help patients in need. A well-suited applicant will have great laboratory skills, a strong analytical mindset, deep scientific curiosity, and a can‑do attitude. The successful candidate will be responsible for the development, optimization, and implementation of various biophysical based screening assays for novel therapeutic candidates with guidance from the lead Scientist.

Essential Functions:

• Conduct routine and novel affinity/kinetic characterization screens on all relevant platforms (Carterra, Octet, Biacore, KinExA), including custom assays and assay development
• Instrument housekeeping, reagent ordering, troubleshooting
• Data summarizing and reporting (ELN, Screener, Benchling, slide decks), timely documentation

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The highly motivated professional we seek is a collaborative team player with these qualifications.

Basic Qualifications:

Doctorate degree

OR

Master’s degree & 3 years of related experience

OR

Bachelor’s degree & 5 years of directly related experience

Preferred Qualifications:

• Deep understanding of molecular binding interaction theory (SPR, BLI), hands on experience and instrumentation nuances – specifically Biacore, ideally 1K/8K series, KinExA experience strongly preferred
• A good understanding of protein chemistry and/or a general biochemistry background; antibody experience desired
• Experience with mammalian cell culture (CHO, HEK) and transfection; on cell affinity assays or FACS is preferred
• Experience with data analysis using PRISM, Codex and custom R/Python is an asset
• A keen eye and a strong analytical mindset, with an interest and aptitude for DoE tasks (e.g. assay dev/troubleshooting) and data analysis and interpretation
• Ability to multitask and stay organized in the face of shifting priorities without losing focus

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for our teammates’ professional and personal growth and well-being.

Amgen is proud to have been recognized as one of LinkedIn Top 25 Companies in Canada for career growth. Click HERE for more details.

In addition to the base salary, Amgen offers competitive and comprehensive Total Rewards Plans that are aligned with local industry standards.

Salary Range

109,254.75CAD -147,815.25CAD