Senior Research Associate – Single B Cell Screening & Functional Antibody Discovery

Kisoji Biotechnology Inc.; Toronto; On-site; CAD 80,000 - 120,000; Full time

Benefits offered by this job

Health and Dental Insurance Plans

Paid Vacation and Holidays

Annual Performance Reviews with Yearly Bonuses

Job summary

Kisoji Biotechnology Inc. in Toronto, Ontario, is seeking a Senior Research Associate to lead antibody discovery workflows utilizing advanced technologies like the CellCelector. This hands-on laboratory role involves planning and executing single B cell screening, working closely with interdisciplinary teams. The ideal candidate has an M.Sc. in a related field, with 5-7 years of industry experience, including hands-on antibody discovery. A competitive salary of $80,000–120,000 CAD is offered along with health insurance and performance bonuses.

Qualifications

• 5–7 years of industry experience in relevant fields.
• 3+ years of hands-on experience in single-cell screening workflows.
• Strong attention to detail and excellent organizational skills.

Responsibilities

• Plan and execute single B cell and plasma cell screening workflows.
• Optimize the CellCelector platform for antibody discovery applications.
• Collaborate with multidisciplinary teams across various functions.

Skills

Hands-on experience in antibody discovery

Mammalian cell culture

Flow cytometry

Troubleshooting and problem-solving

Strong verbal and written communication

Education

M.Sc. in Immunology, Cell Biology, Molecular Biology, Biotechnology, or Bioengineering

Tools

CellCelector

FACS / flow cytometry systems

Job description

KisoJi Biotech is advancing next-generation antibody therapeutics through the integration of proprietary transgenic heavy chain-only antibody (HCAb) platforms, AI-guided discovery, functional screening technologies, and high-throughput single-cell screening systems.

We are currently expanding our antibody discovery capabilities and are seeking two Senior Research Associates to lead and support our single B cell screening and functional antibody discovery workflows using advanced technologies including the CellCelector platform and potentially droplet microfluidics-based screening systems.

This is a highly hands-on laboratory role focused on screening plasma B cells following immunization campaigns to identify antibodies with desirable binding and/or functional activity. The position will involve close collaboration with multidisciplinary teams spanning molecular biology, protein engineering, AI-guided discovery, and functional assay development.

The successful candidates will thrive in a fast-paced biotech environment, demonstrate strong experimental rigor, work independently, and contribute scientifically to the development of next-generation antibody discovery technologies.

Position

Senior Research Associate

Department

Assay Development

Responsibilities

• Plan and execute single B cell and plasma cell screening workflows following animal immunization campaigns
• Operate and optimize the CellCelector platform for single-cell isolation, imaging, clone recovery, and antibody discovery applications
• Develop and execute screening assays for:
• Cell-based functional activity
• Support the implementation and optimization of droplet microfluidics-based screening technologies for high-throughput functional antibody discovery
• Perform mammalian cell culture and support functional screening workflows using reporter assays, flow cytometry, imaging systems, and cell-based assays
• Troubleshoot methods, improve workflows, and contribute to the development of new antibody discovery technologies
• Maintain accurate experimental records and clearly communicate results through reports, presentations, and team discussions
• Assist in SOP development, workflow standardization, and laboratory organization
• Collaborate closely with multidisciplinary teams across discovery, assay development, computational biology, and protein engineering
• Participate in project planning, prioritization, and technology evaluation discussions

Essential Qualifications

• M.Sc. in Immunology, Cell Biology, Molecular Biology, Biotechnology, Bioengineering, or a related field with at least 5–7 years of industry experience
• Minimum 3 years of hands-on experience in antibody discovery or single-cell screening workflows
• Experience with mammalian cell culture and cell-based functional assays
• Experience operating advanced screening or cell handling instrumentation such as:
• CellCelector
• FACS / flow cytometry systems
• Experience with one or more of the following:
• Single B cell screening
• Functional antibody screening
• Reporter-based functional assays
• Strong troubleshooting and problem-solving skills with the ability to independently optimize assays and workflows
• Excellent organizational skills and attention to detail
• Ability to work independently while effectively collaborating within cross-functional teams
• Strong verbal and written communication skills
• Legally authorized to work in Canada

Assets

• Experience with droplet microfluidics systems for single-cell or functional screening
• Experience with flow cytometry assay development and cell sorting
• Experience with reporter assays, imaging-based screening, or phenotypic screening
• Familiarity with automation and high-throughput screening systems
• Experience in oncology or GPCR-focused therapeutic discovery programs

What We Offer

Benefits Package Includes

• Health and Dental Insurance Plans
• Paid Vacation and Holidays

Incentive Programs Include

• Training & Development Programs / Courses
• Annual Performance Reviews with Yearly Bonuses
• Opportunity to work with cutting-edge antibody discovery technologies
• Exposure to advanced AI-guided therapeutic discovery platforms

The salary range for this position is $80,000–120,000 CAD, depending on experience, technical expertise, and qualifications. Compensation will take into account internal equity, work location, and relevant industry experience.

KisoJi Biotech is a collaborative and science-driven organization where innovation, teamwork, and scientific rigor are highly valued. Together, we believe we can help shape the future of antibody therapeutics and contribute meaningfully to the development of transformative medicines.