Research Associate in Next-Generation RNA Therapeutics at UBC

University of British Columbia; Vancouver; On-site; CAD 69,000 - 93,000; Full time

Job summary

The University of British Columbia invites applications for a Research Associate in Next-Generation RNA Therapeutics at the Blakney group in the Michael Smith Laboratories, Vancouver. The appointment focuses on designing polymers for RNA delivery and evaluating immunogenicity in preclinical models.

The successful candidate will join an interdisciplinary team and contribute to projects aimed at clinically translatable RNA therapies, under co-supervision of Dr. Anna Blakney and Dr.

Qualifications

• PhD in chemistry, biomedical engineering, chemical engineering or similar with excellent publication record.
• Background in polymer synthesis, organic chemistry, or lipid synthesis.

Responsibilities

• Design and synthesize novel polymers for RNA delivery.
• Test polymer systems for RNA delivery and immunogenicity in preclinical models.
• Collaborate with Blakney and Kizhakkedathu labs on translational RNA therapeutics.

Skills

Polymer synthesis

Organic chemistry

Lipid synthesis

Education

PhD in chemistry or biomedical/chemical engineering

Job description

Academic Job Category Faculty Non Bargaining Job Title Research Associate in Next-Generation RNA Therapeutics at UBC Department Research | Blakney | Michael Smith Laboratories | Faculty of Science (Anna Blakney (On Leave)) Posting End Date November 14, 2026 Note: Applications will be accepted until 11:59 PM on the Posting End Date. Job End Date May 17, 2029 The expected pay for this position is $80,764 per year.

The Michael Smith Laboratories at the University of British Columbia in Vancouver, Canada, invites applications for a Research Associate position in Next-Generation RNA Therapeutics to join a dynamic and multidisciplinary team under the co-supervision of Dr. Anna Blakney and Dr. Jay Kizhakkedathu.

The successful candidate will work on a project to develop new polymeric strategies for delivery of RNA.

The Blakney Lab at UBC (blakneylab.msl.ubc.ca) develops next-generation RNA vaccines and therapies based on self-amplifying RNA and using interdisciplinary approaches including bioengineering, immunology, molecular biology and bioinformatics.

The Kizhakkedathu lab (https://cbr.ubc.ca/our-people/investigators/jayachandran-kizhakkedathu/) develops novel polymers and biomaterials as therapeutics and devices.

Project: RNA medicines have gained considerable momentum in the past few years with the approval of Onpattro and the COVID-19 messenger RNA vaccines. While lipid nanoparticles (LNPs) are the state-of-the-art delivery system for RNA, we recently discovered that polymeric nanoparticles are less inflammatory and induce higher protein expression than LNPs. For this project, we are keen to explore the polymer design space for RNA delivery for a variety of applications.

The PDF will work with the Blakney and Kizhakkedathu labs to design and synthesize novel polymers, and test them for RNA delivery and immunogenicity in vivo in preclinical models. We anticipate that polymers are a clinically translatable delivery system for RNA therapeutics.

Candidate:

We are hiring polymer chemists with a background in polymer synthesis, organic chemistry and or lipid synthesis. Candidates must have a Ph.D. in chemistry, biomedical engineering, chemical engineering, or similar fields with excellent publication record. The candidate must be able to work well on a team, even in situations where an opportunity is more exciting and time-sensitive than normal. We are seeking a creative individual with great interpersonal skills and excellent communication, both written and verbal.

The appointment will be for two years commencing May 18, 2027 with a possibility for extension, subject to satisfactory performance and funding.

Opportunity:

This is a unique opportunity for several reasons. First, you will be a member of a fun, diverse and interdisciplinary group. Second, you will learn about RNA gene therapies and different aspects of its delivery. Third, you will be actively involved in projects that are intended for clinical translation. Finally, the University of British Columbia is located in Vancouver, which is world-renowned for its scenery and quality of living. UBC is a center of excellence for growing your career in nanomedicine and gene delivery technologies, and you will have opportunities to collaborate with world-class leaders in the field through the Nanomedicine Innovation Network.

Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person.

UBC - One of the World's Leading Universities As one of the world's leading universities, the University of British Columbia creates an exceptional learning environment that fosters global citizenship, advances a civil and sustainable society, and supports outstanding research to serve the people of British Columbia, Canada and the world.

UBC hires on the basis of merit and is committed to employment equity. All qualified persons are encouraged to apply.

Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, and/or Indigenous person. All qualified candidates are encouraged to apply; however Canadians and permanent residents will be given priority.

If you have any accommodation or accessibility needs during the job application process, please contact the Centre for Workplace Accessibility at [e-mail].