Research Associate II, Protein Engineering

Rippling, Inc.; Vancouver; On-site; CAD 70,000 - 100,000; Full time

Benefits offered by this job

Vacation and paid time off

Medical, dental and vision benefits by

Zymelife health and wellness benefits

Employee Share Purchase Program

Employee Equity Program

Volunteer time off

Job summary

Zymeworks in Vancouver, BC (onsite) seeks a scientist to perform protein purification and analytical characterization of protein-based molecules. You will design experiments to characterize multispecific antibody therapeutics and assist in affinity measurements, while troubleshooting and writing SOPs.

The role emphasizes data-driven decisions and collaboration across teams to advance innovative medicines. The successful candidate will have a BSc in biochemistry/immunology (Master's preferred)

Qualifications

• Bachelor's in biochemistry, immunology or a related field required orMaster's with relevant experience.
• Hands-on protein purification experience (affinity, protein A/G/L, IEX, SEC).
• Experience with protein analytical techniques (PAGE, CE-SDS, ELISA, MSD, UPLC-SEC).
• Familiarity with developability assays (AC-SINS, non-specific ELISA, HIC).
• Knowledge of affinity measurements (SPR, BLI, KinExA, on-cell).
• Strong collaboration and data presentation skills.

Responsibilities

• Perform protein purification and analytical characterization of protein-based molecules.
• Design, plan and execute experiments to characterize multispecific antibody therapeutics.
• Assist in affinity measurements to screen protein therapeutics.
• Troubleshoot methods, suggest improvements and develop new technologies.
• Write SOPs for methods requiring technical understanding and calculations.
• Analyze data, draw conclusions and participate in cross-departmental activities.
• Maintain a clean, organized and compliant lab environment.
• Foster effective cross-functional collaboration across the organization.

Skills

Protein purification

Protein analytics

Developability assays

Affinity measurement

Team collaboration

Organizational skills

Data presentation

Education

Bachelor's in biochemistry/immunology

Master's degree (preferred)

Job description

Company Description

Zymeworks is a global biotechnology company managing a portfolio of licensed healthcare assets and developing a diverse pipeline of novel, multifunctional biotherapeutics to improve the standard of care for difficult-to-treat diseases, including cancer, inflammation, and autoimmune disease. The Company’s asset and royalty aggregation strategy focuses on optimizing positive future cash flows from an emerging portfolio of licensed products such as Ziihera® (zanidatamab-hrii) and other licensed products and product candidates such as pasritamig. In addition, Zymeworks is also building a portfolio of healthcare assets that can generate strong cash flows, while supporting the early-stage development of innovative medicines. We are a global company headquartered in Vancouver BC, with operations in Bellevue WA, Dublin IRE, and Singapore.

Why Work With Us

Nothing is more critical to our success than the quality of our team. The work we do is meaningful and impactful - we care about each other as well as the patients we serve. We offer challenging career opportunities, competitive benefits and an environment that recognizes and rewards performance.

This role will be located in Vancouver, BC and is full-time onsite.

What You'll Do

• Perform protein purification and analytical characterization of various protein-based molecules.
• Design, plan and execute experiments to characterize multispecific antibody-based therapeutics through developability assays.
• May assist in affinity measurements to screen protein therapeutics.
• Troubleshoot methods, suggest improvements and develop new technologies for project advancement.
• Write standard operating procedures for methods requiring significant technical understanding, data manipulation and calculations.
• Analyze data, draw conclusions and participate in cross-departmental activities.
• Maintain a clean, organized and operational lab.
• Conduct all activities in accordance with scientific standards, OH&S regulations and established policies and practices.
• Actively work to foster an environment of effective and collaborative working relationships across the organization.

What You'll Bring

• A BSc in a relevant scientific discipline (biochemistry, immunology, etc.) and a minimum of 2-3 years related experience or a Master’s degree with an equivalent combination of education and experience.
• Hands-on experience in protein purification (affinity, protein A/G/L, IEX, and SEC).
• Experience in protein analytical techniques (e.g. PAGE, CE-SDS, ELISA, MSD, UPLC-SEC).
• Knowledge in therapeutics developability assays (AC-SINS, non-specific ELISA, HIC).
• Understanding of different affinity measurement methods (e.g. SPR, BLI, KinExA, on-cell binding).
• Ability to work collaboratively as a member of cross-functional team.
• Good organizational skills and the ability to work effectively in a high paced, fast changing environment.
• Ability to present data at team and inter-departmental meetings.

Total Rewards

We offer a comprehensive total rewards package, which includes competitive salaries, generous benefits, an outstanding work environment, and excellent opportunities for professional growth. We regularly benchmark our compensation against leading biotechnology companies in our geographies.

The base salary range displayed on each job posting reflects the minimum and maximum target for new hire salaries for the position in the location for which the job is posted and does not include bonus, equity, or benefits. Within the range, individual pay is determined by a variety of factors and the salary offered may vary depending on the successful candidate’s location and qualifications (including, but not limited to, job-related knowledge, education, training, skills, and experience).

Our total rewards package that includes:

• Industry leading vacation and paid time off
• Exceptional medical, dental and vision benefits by country
• Zymelife health and wellness benefits
• Employee Share Purchase Program
• Employee Equity Program
• Paid time off to volunteer in your community

This role is not eligible for relocation or immigration support.

All qualified applicants will receive consideration for employment without regard to race, colour, religion, sex, sexual orientation, gender identity, national origin or disability.

NOTE TO AGENCIES

Zymeworks values our relationships with our recruiting partners. We only accept resumes from those partners who have been contracted with us. Zymeworks is not responsible for any fees related to resumes that are unsolicited or are received without contract.