Postdoc: Neuroimmunology & Brain Organoids - Multi-Omics

University of British Columbia; Vancouver; On-site; CAD 65,000 - 75,000; Full time

Job summary

The University of British Columbia invites applications for a Postdoctoral Research Fellow in Human Neuroimmunology, Brain Organoids and Multi‑omics within the Department of Medicine, Faculty of Medicine. The position focuses on hiPSC‑derived brain organoids, neuroimmune interactions, CRISPR engineering, and high‑throughput omics to uncover disease mechanisms.

The successful candidate will join an international team at DMCBH with access to advanced imaging, sequencing, and computational

Qualifications

• PhD (or equivalent) in neuroscience, immunology, stem cell biology, molecular biology, genetics, biomedical engineering, or a closely related discipline.
• Ph.D. within 5 years or M.D./D.D.S. within 10 years.
• Demonstrated research excellence through peer‑reviewed publications.

Responsibilities

• Design and lead innovative research projects investigating mechanisms of neuroinflammation and neurodegeneration.
• Generate and characterize human brain organoids and neural assembloids derived from hiPSCs.
• Differentiate hiPSCs into neural cell populations including neurons, astrocytes, oligodendrocytes, and microglia.
• Develop complex neuroimmune co‑culture systems incorporating immune cells into human CNS models.
• Apply CRISPR/Cas‑based genome engineering technologies to investigate disease‑associated genes and signalling pathways.
• Perform functional immunological experiments investigating immune‑cell activation, cytokine responses, antibody‑mediated mechanisms, complement activation, and neuroimmune communication.
• Apply advanced microscopy techniques including confocal microscopy, live‑cell imaging, high‑content imaging, and three‑dimensional image analysis.
• Perform and integrate high‑dimensional molecular analyses, including single‑cell RNA sequencing, spatial transcriptomics, proteomics, immune repertoire sequencing, and other multi‑omics technologies.
• Collaborate with computational scientists to analyse large‑scale datasets using state‑of‑the‑art bioinformatics and artificial intelligence approaches.
• Prepare manuscripts for publication in leading international journals.
• Present research findings at national and international scientific meetings.
• Contribute to grant applications and collaborative research initiatives.
• Mentor graduate students, undergraduate trainees, and research assistants within the laboratory.
• Contribute to establishing a collaborative, inclusive, and scientifically stimulating research environment.

Education

PhD in neuroscience/immunology/stem cell biology/molecular biology/genetics/biomedical engineering

Job description

The University of British Columbia invites applications for a Postdoctoral Research Fellow in Human Neuroimmunology, Brain Organoids and Multi‑omics within the Department of Medicine, Faculty of Medicine. The position focuses on hiPSC‑derived brain organoids, neuroimmune interactions, CRISPR engineering, and high‑throughput omics to uncover disease mechanisms.

The successful candidate will join an international team at DMCBH with access to advanced imaging, sequencing, and computational