Scientist antibody engineering and developability optimization

argenx; Oost-Vlaanderen; Sur place; EUR 68 000 - 94 000; Plein temps

Résumé du poste

argenx is seeking a (Senior) Scientist to drive early development of therapeutic antibodies in Ghent, Belgium. The role focuses on antibody production, purification, analytical characterization, sequence optimization, and developability assessment with strong project-management skills.

You will coordinate late preclinical/early CMC work, collaborate across discovery, analytical, and engineering teams, and contribute to molecule-selection decisions.

Qualifications

• Ph.D. in Biochemistry, Molecular Biology or related field with antibody biology expertise.
• Proactive, independent and collaborative work style.
• Excellent communication and interpersonal skills.
• Fluent in English.

Responsabilités

• Coordinate late preclinical/early CMC activities from construct design through expression and developability evaluation.
• Collaborate with antibody engineering, analytical, computational, and project teams to identify risks and prioritize experiments.
• Provide science-driven recommendations and contribute to molecule-selection decisions.
• For Senior Scientist level, assume greater program leadership and mentorship responsibilities.

Connaissances

Antibody biology

Protein production

Purification

Developability

Sequence optimization

Project management

Formation

PhD in Biochemistry or Molecular Biology

Description du poste

Join us as we transform immunology and deliver medicines that help autoimmune patients get their lives back. argenx is preparing for multi-dimensional expansion to reach more patients through a rich pipeline of differentiated assets, led by VYVGART, our first-in-class neonatal Fc receptor blocker approved for the treatment of gMG, and with the potential to treat patients across dozens of severe autoimmune diseases.

We are building a new kind of biotech company, one that maintains its roots as a science-based start-up and pushes our commitment to innovate across all corners of our business. We strive to inspire and grow our company, our partnerships, our science, and our people, because when we do, we deliver more for patients.

We are seeking a (Senior) Scientist to support the early development of therapeutic antibodies. The successful candidate will combine expertise in antibody and protein production, purification, analytical characterization, antibody engineering, sequence optimization, and developability assessment with strong project-management and organizational skills.

You will bring structure and planning to multidisciplinary late preclinical/early CMC activities, coordinating work from construct and sequence design through expression, purification, QC, and developability evaluation . You will collaborate closely with antibody engineering, discovery, analytical, computational, and project teams to identify risks, prioritize experiments, and support molecule-selection decisions.

The ideal candidate has a strong understanding of manufacturability of antibodies, hands-on experience with recombinant protein production and purification, and practical knowledge of developability risks such as aggregation, viscosity, degradation, stability, solubility, and nonspecific interactions. Experience with antibody sequence optimization, sequence liabilities, protein structure understanding and multiple antibody formats is highly desirable .

We are looking for a structured, proactive, and scientifically rigorous colleague who can work independently, coordinate effectively across teams, and translate complex data into clear recommendations. For Senior Scientist-level candidates, the role will include greater ownership of program strategy, technical leadership, mentoring, and external collaboration.

The job is based in our facility in Ghent, Belgium, and requires on-site presence at least 4 per week.

Desired skills, experience and challenges

• Ph.D. degree in Biochemistry, Molecular Biology or a related field with a demonstrated expertise in antibody biology,
• Embrace a \"Make it happen\" mentality, showing proactive initiative,
• Ability to work independently and collaboratively within a team,
• Excellent communication and interpersonal skills for effective collaboration,
• Strong analytical and problem-solving skills for tackling complex issues,
• Proficient in English, our corporate language, ensuring clarity.

Offer

• The opportunity to strongly shape the organization, contributing to its future direction in antibody development,
• A competitive salary package that comes with a broad range of benefits. The level assigned to this position will be determined based on the relevant experience of the final candidate,
• Working in a human-sized, dynamic, rapidly growing biotech company, providing an engaging work environment,
• The job is based in our facility in Ghent, Belgium, and requires on-site presence at least 4 per week. Our preferred start date is early December 2026, with some flexibility depending on the successful candidate's availability.

The annual base salary hiring range for this position is €68,000.00 - €93,500.00 EUR

This job is eligible to participate in our short-term and long-term incentives program.

The hiring range displayed above is the range of possible base pay compensation that argenx believes in good faith it will pay for this role at the time of this posting. The hiring range is based on the job grade for this position. Individual compensation paid within this range depends on a variety of factors, including, but not limited to, internal equity, prior education and experience, job-related knowledge and demonstrated skills. argenx may pay more or less than the posted range and this range may be modified in the future.

At argenx, all applicants are welcomed in an inclusive environment. They will receive equal consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other applicable legally protected characteristics. argenx is proud to be an equal opportunity employer.