Scientist

Johnson & Johnson; Beerse; Sur place; EUR 55 000 - 83 000; Plein temps

Résumé du poste

Johnson & Johnson is seeking a scientist to develop and validate MRI methods for pharmaceutical materials and dosage forms. You will work with internal and external experts to advance drug product development and analytical investigations, including solid-state NMR in some projects.

The role requires a master’s degree in physics or chemistry with hands-on pre-clinical MRI experience and strong communication skills in English.

Qualifications

• Master’s degree in Physics, Chemistry or related field.
• Experience interpreting imaging and spectroscopic data.
• Hands-on experience with pre-clinical MRI instrumentation is highly preferred.
• Knowledge of solid-state NMR is a plus.

Responsabilités

• Develop and validate MRI methods for pharmaceutical materials, formulations and dosage forms.
• Establish MRI workflows for coating, capsule performance and device functionality.
• Translate imaging data into actionable formulation and process insights for project teams.
• Maintain lab safety and compliance with GMP and regulatory requirements.

Connaissances

Imaging data interpretation

Spectroscopic data interpretation

English communication

Team collaboration

Formation

Master’s degree in Physics, Chemistry or related field

PhD advantageous

Outils

Pre-clinical MRI instrumentation

Solid-state NMR

Description du poste

Imagine your next project joining an international and diverse team of scientists performing advanced analytical characterization of pharmaceutical products and leading global analytical investigations to find innovative solutions for drug product development.

The Scientist will join the Advanced Material Characterization and Investigations (AMCI) group within AD. AMCI is an international and diverse team of scientists performing advanced analytical characterization of pharmaceutical products and leading global analytical investigations for the commercial product portfolio and for the Discovery, Product Development & Supply (DPDS) organization of Janssen R&D.

The Advanced Molecular Analysis (AMA) team of AMCI is a group of analytical centers of excellence in structure elucidation (by high-resolution Mass Spectrometry, solution, solid-state NMR, and MRI), organic trace analysis, excipient & polymer characterization, and oligonucleotide & peptide analytics. Our labs are equipped with state-of-the-art analytical equipment, including a pre-clinical MRI, 600 MHz standard-bore NMR, and 500MHz wide-bore systems (also equipped with pre-clinical MRI options).

We are currently recruiting an enthusiastic, highly motivated Scientist to join our team! For this laboratory-based position you will work together with internal and external specialists in drug product development and analytical development teams to find innovative solutions for the development of MRI methods for active pharmaceutical ingredients (API), drug product in complex formulations and device functionality for drug-delivery systems. To meet the needs of a highly dynamic drug product environment, it would be advantageous if candidates had basic knowledge of solid-state NMR in addition to NMRI expertise.

roles and responsibilities

• Develop and validate MRI methods for pharmaceutical materials, formulations, and dosage forms.
• Establish MRI workflows complementary to CT scan analysis for typical pharmaceutical applications like water ingress and hydration kinetics in tablets, capsules, gels, and complex dosage forms to understand disintegration, swelling, diffusion, and dissolution-related mechanisms.
• Establish MRI workflows complementary to CT scan analysis for coating and capsule performance, including assessment of coating integrity, permeability, delayed-release behaviour, capsule disintegration, and spatial heterogeneity of release-controlling films.
• Establish MRI workflows complementary to CT scan analysis for device functionality for drug-delivery systems where MRI can support non-destructive visualization of internal movement, fluid distribution, filling/emptying behaviour, and functional performance under relevant test conditions.
• Establish MRI workflows complementary to CT scan analysis for sedimentation and resuspendability of suspensions, depots, and dispersed systems by monitoring particle settling, phase separation, redistribution after agitation.
• Translate imaging data into actionable formulation and process insights for project teams.
• Support cross-functional studies involving formulation development, analytical development, material science, and product performance assessment.
• Build internal expertise, standard operating procedures, and fit-for-purpose data interpretation practices for MRI-based characterization.
• Potentially perform basic solid-state NMR experiments.
• Maintain a safe work environment in compliance with all applicable environmental, health, regulatory requirements, GMP and safety regulations.

how to succeed

• Required: a minimum of master’s degree in Physics, Chemistry or related field, with an affinity to complex instrumentation. A Ph.D. in one of these fields is advantageous, but not required.
• Hands-on experience with pre-clinical MRI Instrumentation is highly preferred.
• Experience with interpreting imaging and spectroscopic data and communicating results to a non-expert audience.
• Experience with solid state NMR is a plus.
• Knowledgeable in organic chemistry is a plus.
• Fast learner with scientific curiosity, self-steering, pro-active, creative.
• Open-minded, with the ability to work together as one team in a global environment.
• Good written and spoken communication and presentation skills in English.
• Efficient, flexible, dynamic, results and performance driven.
• Sense of urgency.

This role offers a very competitive hourly rate. This contract will run for 12 months.

you are welcome here

Johnson & Johnson is working to create an inclusive environment where diverse backgrounds, perspectives, and experiences are valued and each and every one of our people feels that they belong and can reach their potential. No matter who they are.

about Johnson & Johnson Innovative Medicine

Patients inform and inspire our science-based innovations, which continue to change and save lives. Applying rigorous science and compassion, we confidently address some of the most complex diseases of our time and unlock the potential medicines of tomorrow.

Our diverse portfolio spans multiple therapeutic areas — Oncology, Immunology, Neuroscience, Cardiovascular, Pulmonary Hypertension, and Retina.

We are continuously working to develop treatments, aspiring to find cures, pioneering the path from lab to life, and championing patients every step of the way.

Diversity, Equity & Inclusion

For more than 130 years, diversity, equity & inclusion (DEI) have been part of our cultural fabric at Johnson & Johnson and woven into how we do business every day. Our commitment to respect the dignity and diversity of all is embedded in our Credo.

We know that the success of our business depends on having the best talent in a workforce that reflects the diverse markets we serve around the world and an inclusive culture that values different perspectives and life experiences. That is why we are working to create an inclusive environment where diverse backgrounds, perspectives and experiences are valued and each one of our people feels that they belong and can reach their potential. No matter who they are. Diversity, Equity & Inclusion at Johnson & Johnson means “You Belong”.