Senior Scientist - GPCR Signaling & Cellular Biology

Universität Wien; Wien; Hybrid; EUR 63,000 - 77,000; Full time

Benefits offered by this job

Work-life balance

Hybrid work option

600 courses for development

Job summary

The University of Vienna invites applications for a Senior Scientist in the Institute of Physiological Chemistry, Faculty of Chemistry. You will lead research on cellular GPCR signaling, work with CRISPR/Cas9 and biosensor assays, and mentor students in a vibrant international team.

The role combines research, teaching, and administration, with a six-year limit and potential extension. Excellent English and collaboration skills are essential; German language skills are desirable.

Qualifications

• Completed doctoral degree/PhD in biochemistry, molecular biology, or a comparable field.
• Solid experience in 2D and 3D cultures of immortalized and primary mammalian cells, including organoids.
• Comprehensive knowledge of modern cell biology techniques including CRISPR/Cas9, live-cell imaging, and biosensor assays (e.g., BRET/FRET).
• In-depth knowledge of GPCR signaling cascades and their molecular regulation.
• Experience with computational/in-silico methods for ligand–receptor analyses and script-based data analysis.
• Demonstrated research competence with international publications; teaching experience in higher education desirable.
• Excellent English language skills (C1); knowledge of German desirable.
• Team-oriented with strong interpersonal and communication skills.

Responsibilities

• Extensive prior experience in cellular and molecular biological characterization using CRISPR/Cas9-mediated knockout/knock-in, live-cell imaging, and biosensor assays.
• Research on intracellular signaling pathways, including second-messenger cascades and GPCR signaling biases.
• Elucidation of cellular signaling networks linking GPCR signaling to physiological processes; in vivo experience preferred.
• Structure–activity analyses exploring ligand regulation of receptor activation; in-silico methods supported by bioinformatics.
• Mentor and supervise Bachelor, Master, and doctoral students; contribute to project proposals and third-party funding efforts.
• Assume administrative responsibilities in research and teaching; independently conduct courses in food chemistry per regulations.

Skills

CRISPR/Cas9

Live-cell imaging

Biosensor assays

GPCR signaling

2D/3D cell culture

Organoids

Computational methods

Data analysis

Teaching

Mentoring

Education

PhD in biochemistry or molecular biology

Tools

BRET/FRET

Bioinformatics

Job description

The University of Vienna invites applications for a Senior Scientist in the Institute of Physiological Chemistry, Faculty of Chemistry. You will lead research on cellular GPCR signaling, work with CRISPR/Cas9 and biosensor assays, and mentor students in a vibrant international team.

The role combines research, teaching, and administration, with a six-year limit and potential extension. Excellent English and collaboration skills are essential; German language skills are desirable.