Senior Scientist: Cellular Signaling & Chemistry

University of Vienna; Wien; On-site; EUR 65,000 - 74,000; Full time

Benefits offered by this job

Work-life balance

International team

Training & Coaching

Public transport accessibility

Fixed-term contract with long-term可能

Job summary

The University of Vienna invites applications for a Senior Scientist in the Institute of Physiological Chemistry, Faculty of Chemistry. You will join Prof.

Veronika Somoza's group to advance cellular and molecular characterization using CRISPR/Cas9, live-cell imaging, and biosensor assays, focusing on GPCR signaling in chemosensory pathways. We seek candidates with a PhD, strong publication record, and experience in 2D/3D cell cultures, in silico methods, and teaching at a higher education

Qualifications

• Completed doctoral degree/PhD in biochemistry, molecular biology, or a comparable field, with a focus on cellular signaling networks, preferably GPCR signal transduction.
• Solid experience in 2D and 3D cultures of immortalized and primary mammalian cells, as well as organoids, including recombinant expression systems, as a basis for functional signaling studies.
• In-depth knowledge of GPCR signaling cascades and their molecular regulation.
• Experience with computational/in-silico methods for investigating ligand–receptor interactions, as well as script-based data analysis platforms.

Responsibilities

• Extensive prior experience in cellular and molecular biological characterization: Application of modern methods such as CRISPR/Cas9-mediated knockout and knock-in systems, live-cell imaging, and biosensor-based assays to investigate receptor functions.
• Research on intracellular signaling pathways, such as the analysis of second-messenger cascades, receptor trafficking, and biased signaling, preferably with a focus on chemosensory GPCR signaling pathways.
• Elucidation of cellular signaling networks: Linking molecular GPCR signaling pathways with higher-level physiological and metabolic processes, ideally with prior experience in in vivo studies.
• Structure–activity analyses: Investigating structure–activity relationships and how the chemical structure of ligands regulates receptor activation, potentially complemented by the use of in-silico methods combined with bioinformatics data analyses.
• Support for early-career researchers: Supervising and training students in chemistry, food chemistry, nutritional sciences, and related disciplines as part of Bachelor’s, Master’s, and doctoral theses.
• Supporting project proposal processes and the acquisition of third-party funding.
• Assuming administrative responsibilities in research and teaching.
• Independently conducting courses, primarily in the field of food chemistry, in accordance with collective bargaining regulations.

Skills

CRISPR/Cas9

Live-cell imaging

GPCR signaling

2D/3D cell culture

Biosensor assays

In silico methods

Biochemistry

English (C1)

Education

PhD in biochemistry / molecular biology

Postdoctoral research experience

Teaching in higher education

Tools

BRET/FRET

Bioinformatics

Job description

The University of Vienna invites applications for a Senior Scientist in the Institute of Physiological Chemistry, Faculty of Chemistry. You will join Prof.

Veronika Somoza's group to advance cellular and molecular characterization using CRISPR/Cas9, live-cell imaging, and biosensor assays, focusing on GPCR signaling in chemosensory pathways. We seek candidates with a PhD, strong publication record, and experience in 2D/3D cell cultures, in silico methods, and teaching at a higher education