Senior Research Chemist - Process Development

Placements24; Vereeniging; Hybrid; ZAR 900,000 - 1,400,000; Full time

Benefits offered by this job

Hybrid work

Advanced lab facilities

Pilot plant access

Job summary

Placements24 in Vereeniging is seeking a Senior Research Chemist focused on Process Development to optimize and scale-up synthesis routes for novel compounds in an industrial R&D environment. You will work with synthetic chemists and engineers to translate laboratory processes to pilot and manufacturing scales, ensuring safety, efficiency, and cost‑effectiveness.

The role requires PhD or Master in Organic/Process Chemistry with 7+ years in process chemistry, DoE, PAT, GMP familiarity, and strong

Qualifications

• Ph.D. or Master's degree in Organic Chemistry, Process Chemistry, or a related discipline.
• Minimum of 7 years of experience in process chemistry or chemical development within the pharmaceutical or fine chemical industry.
• Strong understanding of organic reaction mechanisms, kinetics, and thermodynamics.
• Experience with process optimization techniques, DoE (Design of Experiments), and PAT (Process Analytical Technology).
• Familiarity with GMP requirements and regulatory considerations for process development.

Responsibilities

• Develop and optimize synthetic routes for target molecules, focusing on scalability, safety, and economic viability.
• Conduct process hazard assessments and implement appropriate safety measures.
• Troubleshoot and resolve issues encountered during process scale-up and manufacturing.
• Design and execute experiments to identify critical process parameters and establish control strategies.
• Characterize intermediates and final products using a range of analytical techniques.
• Collaborate with analytical and engineering teams to ensure smooth technology transfer and process validation.

Job description

About the Role

Our client is seeking a dedicated Senior Research Chemist focused on Process Development to join their innovative R&D team in Vereeniging . This role is crucial for optimizing and scaling up chemical synthesis routes for novel compounds, ensuring efficient, safe, and cost-effective production. You will work closely with synthetic chemists and engineers to transition laboratory-scale processes to pilot and manufacturing scales. This is an exciting opportunity for a chemist with a passion for practical application and process optimization in a collaborative industrial environment.

Key Responsibilities

• Develop and optimize synthetic routes for target molecules, focusing on scalability, safety, and economic viability.
• Conduct process hazard assessments and implement appropriate safety measures.
• Troubleshoot and resolve issues encountered during process scale-up and manufacturing.
• Design and execute experiments to identify critical process parameters and establish control strategies.
• Characterize intermediates and final products using a range of analytical techniques.
• Collaborate with analytical and engineering teams to ensure smooth technology transfer and process validation.

Requirements

• Ph.D. or Master's degree in Organic Chemistry, Process Chemistry, or a related discipline.
• Minimum of 7 years of experience in process chemistry or chemical development within the pharmaceutical or fine chemical industry.
• Strong understanding of organic reaction mechanisms, kinetics, and thermodynamics.
• Experience with process optimization techniques, DoE (Design of Experiments), and PAT (Process Analytical Technology).
• Familiarity with GMP requirements and regulatory considerations for process development.
• Excellent problem-solving, communication, and project management skills.

Benefits

• Competitive salary and attractive bonus potential.
• Comprehensive benefits package including health, retirement, and life insurance.
• Hybrid work arrangement offering flexibility.
• Access to advanced laboratory facilities and pilot plant resources in Vereeniging .
• Opportunities for career advancement and professional development within a growing company.