Senior Process Chemist - Pharmaceutical Development

Placements24; LegKraal Gate; Hybrid; ZAR 900,000 - 1,200,000; Full time

Benefits offered by this job

Health insurance

Bonus potential

Continuous education

Job summary

Placements24 seeks a Senior Process Chemist to advance API synthesis and scale-up in a pharmaceutical R&D setting. You will translate laboratory methods into scalable, cost-effective manufacturing processes while collaborating across analytical, formulation, and manufacturing teams.

The role involves developing robust processes, ensuring regulatory compliance, and contributing to life-saving medicines in a hybrid work environment in Mahikeng.

Qualifications

• Ph.D. or Master’s degree in Organic Chemistry, Chemical Engineering, or a related field.
• Minimum of 5 years of experience in process chemistry or pharmaceutical development, focusing on API synthesis.
• Proven expertise in synthetic organic chemistry, process optimization, and scale-up challenges.
• Hands-on experience with analytical techniques for characterization and impurity analysis.
• Familiarity with GMP and ICH guidelines for pharmaceutical manufacturing.
• Excellent problem-solving skills, strong communication abilities, and ability to work in a hybrid team environment.

Responsibilities

• Develop and optimize synthetic routes for APIs and key intermediates with emphasis on yield, purity, safety, and scalability.
• Conduct R&D studies including reaction kinetics, impurity profiling, and crystallization development.
• Scale-up processes from laboratory to pilot and manufacturing scales with successful tech transfer.
• Utilize PAT and statistical methods to monitor and control processes.
• Troubleshoot process-related issues and implement corrective actions for product quality and production efficiency.
• Collaborate with analytical chemists, formulation scientists, and manufacturing personnel to ensure project progression.
• Author and review process descriptions, validation reports, and regulatory documentation.

Skills

Synthetic organic chemistry

Process optimization

Scale-up challenges

GMP / ICH knowledge

Analytical techniques

Problem solving

Communication

Education

Ph.D. or Master’s in Organic Chemistry or Chemical Engineering

Job description

About the Role

Our client is seeking a highly motivated Senior Process Chemist to join their pharmaceutical development R&D team in Mahikeng . This role is crucial for developing and optimizing chemical processes for the synthesis of active pharmaceutical ingredients (APIs) and intermediates. You will be instrumental in translating laboratory-scale syntheses into robust, scalable, and cost-effective manufacturing processes. This position offers a fantastic opportunity to contribute to the development of life-saving medicines within a dynamic, hybrid work setting.

Key Responsibilities

• Develop and optimize synthetic routes for APIs and key intermediates, focusing on yield, purity, safety, and scalability.
• Conduct process research and development studies, including reaction kinetics, impurity profiling, and crystallization development.
• Scale-up chemical processes from laboratory to pilot plant and manufacturing scales, ensuring successful technology transfer.
• Utilize process analytical technology (PAT) and statistical methods to monitor and control chemical processes.
• Troubleshoot process-related issues and implement corrective actions to ensure consistent product quality and efficient production.
• Collaborate with analytical chemists, formulation scientists, and manufacturing personnel to ensure seamless project progression.
• Author and review process descriptions, validation reports, and other regulatory documentation.

Requirements

• Ph.D. or Master's degree in Organic Chemistry , Chemical Engineering, or a related field.
• Minimum of 5 years of experience in process chemistry or pharmaceutical development, with a strong focus on API synthesis.
• Proven expertise in synthetic organic chemistry, process optimization, and scale-up challenges.
• Hands-on experience with various analytical techniques for characterization and impurity analysis.
• Familiarity with regulatory requirements (e.g., GMP) and ICH guidelines for pharmaceutical manufacturing.
• Excellent problem-solving skills, strong communication abilities, and the capacity to work effectively in a hybrid team environment in Mahikeng .

Benefits

• Competitive salary and attractive bonus structure.
• Comprehensive health, dental, and vision insurance.
• Retirement savings plan with employer matching.
• Generous opportunities for professional development and continuing education.
• Hybrid work model combining remote flexibility with essential on-site collaboration.