Process Development Chemist - Pharmaceutical

Placements24; Rustenburg; On-site; ZAR 900,000 - 1,200,000; Full time

Benefits offered by this job

Relocation assistance

Medical aid

Retirement fund contributions

Training opportunities

Bonus potential

Job summary

Placements24 seeks a skilled Process Development Chemist for its pharmaceutical manufacturing facility in Rustenburg. The role focuses on optimizing and scaling chemical processes for APIs, ensuring robust, reproducible methods as production shifts from lab to commercial scale.

The candidate will work to improve yields, purity, and safety, collaborating with engineering and manufacturing teams to implement technology transfer and cost efficiencies. Relocation support may be available.

Qualifications

• Master's or PhD in Organic Chemistry, Chemical Engineering or related field.
• 3–5 years of pharma process development or scale-up experience.
• Strong knowledge of organic synthesis and process chemistry.
• Experience with process safety evaluations and hazard analysis.
• Proficiency in analytical techniques for process monitoring.
• Excellent problem-solving and systematic optimization abilities.

Responsibilities

• Develop, optimize, and validate chemical processes for API synthesis focusing on yield, purity, and scalability.
• Conduct experiments to understand reaction kinetics and establish control strategies.
• Troubleshoot process-related issues during pilot and commercial manufacturing.
• Scale up laboratory processes to pilot and commercial scales with robustness and safety.
• Collaborate with engineering and manufacturing teams for process improvements and technology transfer.
• Generate comprehensive process development reports including hazard assessments and control strategies.

Skills

Process optimization

Scale-up expertise

Analytical techniques

Problem solving

Hazard analysis

Education

Master's or PhD in Organic Chemistry or Chemical Engineering

Job description

About the Role

Our client is looking for a skilled Process Development Chemist to join their innovative pharmaceutical manufacturing facility in Rustenburg . This role focuses on optimizing and scaling up chemical processes for the efficient and safe production of active pharmaceutical ingredients (APIs). You will be a key contributor to ensuring robust and reproducible manufacturing methods, supporting the transition from laboratory-scale synthesis to commercial production. This is an exciting opportunity to work at the forefront of pharmaceutical manufacturing technology in the North West province, driving process improvements and cost efficiencies.

Key Responsibilities

• Develop, optimize, and validate chemical processes for the synthesis of APIs, focusing on yield, purity, and scalability.
• Conduct experiments to understand reaction kinetics, identify critical process parameters, and establish control strategies.
• Troubleshoot and resolve process-related issues encountered during pilot plant and commercial manufacturing.
• Scale up laboratory processes to pilot and commercial scales, ensuring process robustness and safety.
• Collaborate with engineering and manufacturing teams to implement process improvements and technology transfer.
• Generate comprehensive process development reports, including hazard assessments and control strategies.

Requirements

• Master's or Ph.D. in Organic Chemistry, Chemical Engineering, or a related field.
• 3-5 years of experience in pharmaceutical process development or chemical process scale-up.
• Strong knowledge of organic synthesis, reaction mechanisms, and process chemistry principles.
• Experience with process safety evaluations and hazard analysis is essential.
• Proficiency in using analytical techniques for process monitoring and characterization.
• Excellent problem-solving abilities and a systematic approach to process optimization in Rustenburg .

Benefits

• Highly competitive salary and bonus structure.
• Comprehensive medical aid and retirement fund contributions.
• Extensive opportunities for professional growth and training in process chemistry.
• Relocation assistance may be available for qualified candidates.
• A stimulating work environment focused on innovation and continuous improvement.