Senior Process Chemist: API Scale-Up & Optimization - On-Site Sandton

Placements24; Sandton; On-site; ZAR 1,000,000 - 1,400,000; Full time

Benefits offered by this job

Annual bonus

Medical coverage

Retirement plan

Job summary

Placements24 is seeking an experienced Senior Process Chemist for our Sandton, Gauteng facility to lead development, optimization, and scale-up of APIs and intermediates. The role focuses on improving process efficiency, yield, safety, and sustainability from lab to commercial scale.

The ideal candidate has a PhD or MSc in Organic Chemistry, Process Chemistry, or Chemical Engineering, with 6+ years in pharmaceutical process development and scale-up, and a strong grasp of cGMP and regulatory

Qualifications

• Ph.D. or M.Sc. in Organic Chemistry, Process Chemistry, or Chemical Engineering.
• Minimum of 6 years of relevant experience in pharmaceutical process development and scale-up.
• Experience with cGMP environments and regulatory requirements for pharmaceutical manufacturing.

Responsibilities

• Lead process development and optimization projects for synthesis of APIs and pharmaceutical intermediates.
• Design and execute laboratory-scale experiments to explore new routes and improve existing ones.
• Conduct process safety assessments to ensure safe scale-up (e.g., HAZOP studies).
• Develop and optimize process parameters to maximize yield, purity, and efficiency.
• Troubleshoot issues during pilot plant trials and commercial manufacturing.
• Collaborate with engineers to transfer processes from lab to pilot and commercial scale.
• Ensure compliance with cGMP, safety, and environmental regulations.
• Prepare process development reports, transfer documentation, and validation protocols.
• Stay updated on new technologies in process chemistry and pharmaceutical manufacturing.
• Mentor junior chemists and provide technical guidance to the team.

Skills

Organic synthesis

Process chemistry

Scale-up experience

DoE experience

Analytical problem solving

Leadership

Communication skills

Education

PhD or MSc in Organic Chemistry/Process Chemistry/Chemical Engineering

Tools

HPLC

GC

NMR

KF

DSC

Job description

Placements24 is seeking an experienced Senior Process Chemist for our Sandton, Gauteng facility to lead development, optimization, and scale-up of APIs and intermediates. The role focuses on improving process efficiency, yield, safety, and sustainability from lab to commercial scale.

The ideal candidate has a PhD or MSc in Organic Chemistry, Process Chemistry, or Chemical Engineering, with 6+ years in pharmaceutical process development and scale-up, and a strong grasp of cGMP and regulatory