Senior Process Chemist — API Scale-Up & Innovation

Placements24; Vereeniging; On-site; ZAR 900,000 - 1,300,000; Full time

Benefits offered by this job

Competitive salary

Health insurance

Retirement plan

Generous leave

Professional development

On-site cafeteria

Job summary

Placements24 is seeking a Senior Process Chemist for our pharmaceutical development facility in Vereeniging, Gauteng. You will lead API process development, optimize routes, and scale from lab to pilot and commercial production, ensuring GMP compliance.

The role requires a PhD or MSc in Organic Chemistry, Process Chemistry, or Chemical Engineering with 5+ years in pharma process development, strong DoE and process safety expertise, and excellent collaboration across analytical, formulation and

Qualifications

• Ph.D. or master's degree in Organic Chemistry, Process Chemistry or Chemical Engineering.
• Minimum 5 years of pharmaceutical process development and scale-up experience.
• Strong knowledge of organic synthesis, reaction mechanisms, and purification techniques.
• Experience with DoE, process optimization, and process safety assessment.
• Familiarity with GMP regulations and ICH guidelines.
• Proficiency with analytical instrumentation for chemical characterization.
• Excellent problem-solving skills and hands-on approach.
• Strong written and verbal communication; ability to work in a multidisciplinary team.

Responsibilities

• Develop and optimize synthetic routes for APIs and intermediates with focus on efficiency, safety and scalability.
• Conduct process research including parameter screening, DoE and kinetic studies.
• Scale up chemical processes from lab to pilot plant and commercial manufacturing.
• Troubleshoot and resolve technical issues in process development and manufacturing.
• Implement PAT and other advanced control strategies.
• Ensure all processes comply with GMP and regulatory guidelines.
• Perform PHAs and establish safe operating procedures.
• Characterize materials using analytical techniques (HPLC, GC, NMR, MS).
• Collaborate with analytical, formulation and engineering teams for project progression.

Skills

Organic synthesis

Reaction mechanisms

Purification techniques

Process optimization

DoE

Process safety assessment

GMP compliance

Education

Ph.D./MSc in Organic Chemistry, Process Chemistry or Chemical Engineering

Tools

Analytical instrumentation

Job description

Placements24 is seeking a Senior Process Chemist for our pharmaceutical development facility in Vereeniging, Gauteng. You will lead API process development, optimize routes, and scale from lab to pilot and commercial production, ensuring GMP compliance.

The role requires a PhD or MSc in Organic Chemistry, Process Chemistry, or Chemical Engineering with 5+ years in pharma process development, strong DoE and process safety expertise, and excellent collaboration across analytical, formulation and