Senior Principal Statistical Programmer - SAS + R (Remote)

Advtech; South Africa; Remote; ZAR 1,000,000 - 1,600,000; Full time

Job summary

Cytel Inc. seeks a Senior/Principal Statistical Programmer (Remote) to lead programming for sponsor clinical trials across therapeutic areas.

You will deliver SDTM/ADaM specifications, develop SAS and R code, review CRO outputs, and support regulatory submissions. Ideal candidates have 7+ years in clinical programming, deep CDISC expertise, strong communication, and the ability to work independently with minimal supervision.

Qualifications

• Minimum bachelor’s degree in computer science, data science, mathematics or statistics.
• 7+ years of experience as Statistical Programmer in Biotech/Pharma clinical development biometrics.
• Exceptional SAS programming skills and regulatory submission experience.
• Strong knowledge of CDISC standards (SDTM/ADaM/Define.xml) and FDA/ICH regulations.

Responsibilities

• Generate SDTM, ADaM specifications, datasets, and define.xml for multiple studies.
• Develop SAS programs to create datasets, tables, listings, and graphs.
• Deliver high-quality SAS and R programs for clinical development programs.
• Oversee CRO programming deliverables to meet timelines and quality.
• Support clinical study reports, regulatory submissions, and exploratory analyses.
• Contribute to SOPs, data transfer specs, and data validation plans.

Skills

SAS programming

R programming

CDISC standards

Regulatory submissions

CRO oversight

Leadership

Communication skills

Unix/Linux basics

Education

Bachelor's degree in computer science / data science / mathematics / statistics

Tools

SAS

R

CDISC tooling

Job description

Cytel Inc. seeks a Senior/Principal Statistical Programmer (Remote) to lead programming for sponsor clinical trials across therapeutic areas.

You will deliver SDTM/ADaM specifications, develop SAS and R code, review CRO outputs, and support regulatory submissions. Ideal candidates have 7+ years in clinical programming, deep CDISC expertise, strong communication, and the ability to work independently with minimal supervision.