Senior Principal Statistical Programmer – SAS + R (Remote)

University Of Fort Hare; Johannesburg; Remote; ZAR 900,000 - 1,500,000; Full time

Job summary

Cytel Inc. invites an experienced Senior/Principal Statistical Programmer to lead programming activities on global clinical trials, with SDTM/ADaM specifications, define.xml and data review. This remote role emphasizes autonomy and high-quality outputs across studies.

You will develop SAS programs, extend with R capabilities, oversee CRO deliverables, and support regulatory submissions while adhering to FDA/ICH guidance. Strong communication and leadership are essential for success.

Qualifications

• Must have a bachelor-level degree in a relevant field with strong statistical programming background.
• Experience implementing CDISC SDTM/ADaM standards and Define.xml.
• Experience in clinical development and regulatory submissions.

Responsibilities

• Generate SDTM, ADaM specifications, datasets, reviewer's guide and define.xml files for multiple studies
• Develop SAS programs which generate datasets, complex listings, tables and graphs
• Deliver high-quality statistical programming results including SAS and/or R programs
• Participate in overseeing CRO's statistical programming deliverables for multiple studies
• Support the preparation of clinical study reports, regulatory submissions, publications
• Follow FDA/ICH guidance for electronic submissions
• Contribute to standards for programming tools, outputs, and macros
• Collaborate with internal and external functions to meet timelines

Skills

SAS programming

R programming

Leadership

Communication skills

Independent work

Education

Bachelor's degree in computer science, data science, mathematics, or statistics

Tools

SAS

R

Python

Java

Shiny

Unix/Linux

Git

Job description

Cytel Inc. invites an experienced Senior/Principal Statistical Programmer to lead programming activities on global clinical trials, with SDTM/ADaM specifications, define.xml and data review. This remote role emphasizes autonomy and high-quality outputs across studies.

You will develop SAS programs, extend with R capabilities, oversee CRO deliverables, and support regulatory submissions while adhering to FDA/ICH guidance. Strong communication and leadership are essential for success.