Senior Pharmaceutical Chemist (Analytical Development)

Placements24; Vereeniging; On-site; ZAR 900,000 - 1,300,000; Full time

Benefits offered by this job

Medical aid

Retirement fund

Life insurance

Performance bonuses

Annual leave

Advanced training programs

Job summary

Placements24 is seeking a Senior Pharmaceutical Chemist specializing in Analytical Development for our Vereeniging facility to lead the development, validation, and implementation of methods ensuring product quality.

The role requires extensive experience in pharmaceutical analysis and a track record of solving complex analytical challenges, with collaboration across R&D, manufacturing, and regulatory affairs in a fast-paced environment.

Qualifications

• Ph.D. or Master’s in Analytical, Organic, Pharmaceutical Chemistry or related field.
• Minimum 6 years of analytical method development and validation in pharma.
• Expertise with HPLC/UPLC and GC.
• Strong knowledge of ICH guidelines and GMP regulatory submissions.
• Experience with impurity profiling and stability testing.
• Excellent scientific writing and verbal communication abilities.

Responsibilities

• Develop and validate analytical methods for raw materials, in-process controls, and finished products (HPLC, GC, LC-MS, GC-MS, ICP-MS, spectroscopy).
• Transfer methods to QC labs and provide ongoing support.
• Troubleshoot and optimize analytical methods for efficiency and robustness.
• Characterize impurities and degradation products of pharmaceutical compounds.
• Conduct stability studies and analyze data.
• Prepare validation protocols and reports per ICH and regulatory guidelines.
• Collaborate with R&D, manufacturing, and regulatory affairs.
• Maintain lab equipment and ensure GLP/GMP compliance.
• Contribute to regulatory submissions with analytical data.
• Mentor junior analytical chemists.

Skills

Analytical chemistry

HPLC/UPLC

GC

ICH & GMP knowledge

Impurity profiling

Stability testing

Scientific writing

Project management

Data analysis software

LIMS familiarity

Education

Ph.D. or Master’s in Analytical/Organic/Pharmaceutical Chemistry

Tools

LIMS

Data analysis software

Job description

About the Role

Our client, a leader in pharmaceutical innovation, is seeking a highly experienced Senior Pharmaceutical Chemist specializing in Analytical Development to join their cutting-edge facility in Vereeniging, Gauteng . This critical role will be responsible for the development, validation, and implementation of analytical methods used to characterize and control the quality of new and existing pharmaceutical products. The ideal candidate possesses a strong analytical chemistry background, extensive experience with pharmaceutical analysis, and a passion for scientific problem-solving. This is an exceptional opportunity to make a significant contribution to drug development and quality control within a renowned organization located in the industrial heartland of Vereeniging .

Key Responsibilities

• Develop and validate novel analytical methods for raw materials, in-process controls, and finished products using techniques such as HPLC, GC, LC-MS, GC-MS, ICP-MS, and spectroscopy.
• Transfer analytical methods to QC laboratories and provide ongoing support.
• Troubleshoot and optimize existing analytical methods to improve efficiency, accuracy, and robustness.
• Characterize impurities and degradation products of pharmaceutical compounds.
• Conduct stability studies and analyze associated data.
• Author and review validation protocols, reports, and method descriptions in accordance with ICH and other regulatory guidelines.
• Collaborate with cross-functional teams, including R&D, manufacturing, and regulatory affairs, to support product development and lifecycle management.
• Maintain laboratory equipment and ensure compliance with GLP and GMP standards.
• Contribute to regulatory submissions by providing comprehensive analytical data and documentation.
• Mentor junior analytical chemists and provide technical guidance.

Requirements

• Ph.D. or Master's degree in Analytical Chemistry, Organic Chemistry, Pharmaceutical Chemistry, or a related field.
• A minimum of 6 years of relevant experience in analytical method development and validation within the pharmaceutical industry.
• Expertise in a wide range of analytical instrumentation, particularly HPLC/UPLC and GC.
• Thorough understanding of ICH guidelines, GMP, and regulatory submission requirements.
• Proven experience in impurity profiling and stability testing.
• Strong problem-solving and critical thinking skills.
• Excellent scientific writing and verbal communication abilities.
• Ability to manage multiple projects and meet deadlines in a fast-paced environment.
• Experience with data analysis software and LIMS.
• Familiarity with contract research organizations (CROs) and contract manufacturing organizations (CMOs) is advantageous.

Benefits

Our client offers a highly competitive salary, a comprehensive benefits package including medical aid, retirement fund, and life insurance, along with significant opportunities for professional growth and advancement. This position is based in Vereeniging, Gauteng , offering a strategic location within a key industrial region. We are committed to fostering a stimulating research environment and supporting our employees' career aspirations. Additional benefits include performance bonuses, generous annual leave, and access to advanced training programs. Join our team and contribute to the development of life-changing medicines.