Senior Organic Chemist: API Synthesis & Process Development

Placements24; Bloemfontein; On-site; ZAR 900,000 - 1,400,000; Full time

Benefits offered by this job

Competitive salary package

Medical benefits

Retirement benefits

Professional development and education

Modern laboratories

Job summary

Placements24 in Bloemfontein, South Africa, seeks a Senior Organic Chemist to design and optimize synthetic routes for APIs and scale-up processes in a state-of-the-art facility.

You will work with a multidisciplinary team to advance drug candidates from discovery through early manufacturing, applying GMP knowledge and advanced analytical techniques to ensure robust, scalable chemistry and compliance with safety standards.

Qualifications

• PhD in organic chemistry or related field required.
• Minimum 5 years industrial experience in synthesis or process chemistry.
• Proven ability to design and execute complex synthetic routes.
• Strong knowledge of reaction mechanisms, stereochemistry, and modern methods.
• Experience with GMP and scalable manufacturing is essential.

Responsibilities

• Design and synthesize complex APIs and intermediates.
• Develop scalable multi-step routes for manufacturing.
• Troubleshoot challenging reactions and purification steps.
• Analyze reactions using NMR, MS, HPLC, and GC.
• Collaborate with process engineers for technology transfer.
• Maintain detailed lab notebooks and prepare technical reports.
• Stay updated on advances in organic synthesis and process chemistry.
• Ensure compliance with safety regulations and quality standards.
• Contribute to patents and scientific publications.

Skills

Organic synthesis design

Process development

Scale-up expertise

Team collaboration

Problem solving

Effective communication

Education

PhD in Organic Chemistry

Tools

NMR

MS

HPLC

GC

Job description

Placements24 in Bloemfontein, South Africa, seeks a Senior Organic Chemist to design and optimize synthetic routes for APIs and scale-up processes in a state-of-the-art facility.

You will work with a multidisciplinary team to advance drug candidates from discovery through early manufacturing, applying GMP knowledge and advanced analytical techniques to ensure robust, scalable chemistry and compliance with safety standards.