Senior Organic Chemist - Synthesis and Process Development

Placements24; Bloemfontein; Presencial; ZAR 900.000 - 1.400.000; Jornada completa

Ventajas ofrecidas por este puesto de trabajo

Competitive salary package

Medical benefits

Retirement benefits

Professional development and education

Modern laboratories

Descripción de la vacante

Placements24 in Bloemfontein, South Africa, seeks a Senior Organic Chemist to design and optimize synthetic routes for APIs and scale-up processes in a state-of-the-art facility.

You will work with a multidisciplinary team to advance drug candidates from discovery through early manufacturing, applying GMP knowledge and advanced analytical techniques to ensure robust, scalable chemistry and compliance with safety standards.

Formación

• PhD in organic chemistry or related field required.
• Minimum 5 years industrial experience in synthesis or process chemistry.
• Proven ability to design and execute complex synthetic routes.
• Strong knowledge of reaction mechanisms, stereochemistry, and modern methods.
• Experience with GMP and scalable manufacturing is essential.

Responsabilidades

• Design and synthesize complex APIs and intermediates.
• Develop scalable multi-step routes for manufacturing.
• Troubleshoot challenging reactions and purification steps.
• Analyze reactions using NMR, MS, HPLC, and GC.
• Collaborate with process engineers for technology transfer.
• Maintain detailed lab notebooks and prepare technical reports.
• Stay updated on advances in organic synthesis and process chemistry.
• Ensure compliance with safety regulations and quality standards.
• Contribute to patents and scientific publications.

Conocimientos

Organic synthesis design

Process development

Scale-up expertise

Team collaboration

Problem solving

Effective communication

Educación

PhD in Organic Chemistry

Herramientas

NMR

MS

HPLC

GC

Descripción del empleo

About the Role

Our client, a dynamic pharmaceutical company focused on innovative drug development, is seeking a highly skilled Senior Organic Chemist with expertise in synthesis and process development. This role is located in Bloemfontein, Free State . You will be instrumental in designing and executing synthetic routes for novel active pharmaceutical ingredients (APIs) and optimizing existing processes for scale-up and manufacturing. The ideal candidate will possess a strong foundation in organic synthesis, reaction mechanisms, and analytical techniques, coupled with practical experience in process chemistry. You will work closely with a multidisciplinary team of scientists and engineers to advance drug candidates from discovery through to clinical trials. This is an exciting opportunity to contribute to the development of new medicines in a state-of-the-art research facility in South Africa , based in the capital city of Bloemfontein .

Key Responsibilities

• Design and synthesize complex organic molecules, including APIs and key intermediates.
• Develop and optimize multi-step synthetic routes suitable for scale-up and manufacturing.
• Investigate and troubleshoot challenging chemical reactions and purification processes.
• Perform thorough reaction analysis using techniques such as NMR, MS, HPLC, and GC.
• Implement process safety assessments and develop robust control strategies.
• Collaborate with process engineers to ensure smooth technology transfer to manufacturing sites.
• Maintain detailed laboratory notebooks and prepare comprehensive technical reports.
• Stay updated on the latest advancements in organic synthesis and process chemistry.
• Ensure compliance with all safety regulations and quality standards (e.g., cGMP).
• Contribute to patent applications and scientific publications.

Requirements

• Ph.D. in Organic Chemistry or a closely related field.
• Minimum of 5 years of relevant industrial experience in organic synthesis and/or process chemistry, preferably within the pharmaceutical sector.
• Demonstrated expertise in designing and executing complex synthetic pathways.
• Strong knowledge of reaction mechanisms, stereochemistry, and modern synthetic methodologies.
• Proficiency with a wide range of analytical techniques for compound characterization.
• Experience in process optimization, scale-up, and technology transfer.
• Familiarity with Good Manufacturing Practices (GMP) is essential.
• Excellent problem-solving skills and attention to detail.
• Strong written and verbal communication skills.
• Ability to work independently and collaboratively in a fast-paced R&D environment in Bloemfontein .

Benefits

• Our client offers a competitive salary package, comprehensive medical and retirement benefits, and opportunities for professional development and continuing education.
• Employees work in modern laboratories equipped with advanced instrumentation.
• Join a dedicated team focused on therapeutic innovation in Bloemfontein .
• We provide a supportive and challenging work environment that fosters scientific excellence and career advancement.
• This role is based at our research facility in the Free State province, South Africa .