Senior Clinical Pharmacologist - Translational Research

Placements24; East London; Hybrid; ZAR 1,200,000 - 1,800,000; Full time

Benefits offered by this job

Health insurance

Retirement plan

Generous paid time off

Training and conference support

Job summary

Placements24 in East London is seeking a Senior Clinical Pharmacologist to lead translational research in early-phase development, bridging preclinical work into first-in-human studies and dose-ranging trials.

You will design PK/PD analyses, interact with regulators, mentor scientists, and work cross-functionally to ensure robust pharmacology programs.

Qualifications

• MD/PhD/PharmD with clinical pharmacology expertise in pharma or academia.
• Proven experience in designing and conducting early-phase trials (Phase I/II).
• Strong PK/PD knowledge and data modeling capabilities.
• Familiarity with FDA/EMA guidelines relevant to clinical pharmacology.
• Excellent writing and presentation skills; able to communicate complex data.
• Collaborative mindset for cross-disciplinary team work.

Responsibilities

• Design and oversee clinical pharmacology studies including FIH and DDI.
• Develop PK/PD analysis plans and interpret results.
• Collaborate with biostatisticians for PK/PD analyses.
• Contribute to protocols, investigator brochures, and reports.
• Provide expertise on metabolism, interactions, and patient factors.
• Coordinate with preclinical teams for seamless transition to clinic.
• Interface with regulators to present pharmacology data.
• Shape scientific strategy for early development programs.
• Review literature to inform study design and strategy.
• Mentor junior scientists and uphold scientific rigor.

Skills

Clinical pharmacology

Early-phase trials

PK/PD modeling

Regulatory familiarity

Scientific writing

Cross-functional collaboration

Education

MD, PharmD, or PhD in Pharmacology/Toxicology/Pharmaceutical Sciences

Job description

About the Role

Our client, a pioneering pharmaceutical company focused on accelerating the translation of scientific discoveries into effective medicines, is seeking a Senior Clinical Pharmacologist to join their Translational Research department in **East London**. This critical role will be instrumental in bridging the gap between preclinical research and clinical application, designing and executing studies that elucidate drug mechanisms of action, dose-response relationships, and optimal therapeutic strategies. The Senior Clinical Pharmacologist will contribute significantly to early-phase clinical development, ensuring robust pharmacokinetic and pharmacodynamic assessments. This is an exceptional opportunity for a driven pharmacologist to contribute to impactful drug development in a collaborative and intellectually stimulating environment. The ideal candidate will possess a deep understanding of clinical pharmacology principles and experience in early-phase clinical trials. We are committed to fostering scientific excellence and providing career advancement opportunities within our **East London** team. The **East London** setting provides a focused environment for translational research, contributing to the company's mission to deliver innovative treatments.

Key Responsibilities

• Design and oversee clinical pharmacology studies, including first-in-human (FIH) trials, dose escalation studies, and drug-drug interaction (DDI) studies.
• Develop pharmacokinetic (PK) and pharmacodynamic (PD) analysis plans and interpret study data.
• Collaborate with biostatisticians to ensure appropriate statistical analysis of PK/PD data.
• Contribute to the development of clinical study protocols, investigator brochures, and clinical study reports.
• Provide scientific expertise on drug metabolism, drug interactions, and patient-specific factors affecting drug response.
• Work closely with preclinical teams to ensure seamless transition of candidate drugs into clinical development.
• Interface with regulatory authorities to discuss and present clinical pharmacology data.
• Contribute to the scientific strategy for early drug development programs.
• Review and interpret relevant scientific literature to inform study design and drug development strategy.
• Mentor junior scientists and contribute to the scientific rigor of the department.

Requirements

• M.D., Pharm.D., or Ph.D. in Pharmacology, Toxicology, Pharmaceutical Sciences, or a related discipline.
• A minimum of 5 years of experience in clinical pharmacology within the pharmaceutical industry or academic research.
• Proven experience in designing and conducting early-phase clinical trials (Phase I/II).
• Strong understanding of pharmacokinetic and pharmacodynamic principles and modeling techniques.
• Familiarity with regulatory guidelines for clinical pharmacology studies (e.g., FDA, EMA).
• Excellent scientific writing, presentation, and communication skills.
• Ability to analyze and interpret complex data sets.
• Strong collaborative skills and ability to work effectively in multidisciplinary teams.
• Experience with population PK/PD analysis is highly desirable.
• Commitment to scientific rigor and ethical research practices.

Benefits

Our client offers a competitive salary, performance-based bonuses, and a comprehensive benefits package including health, dental, and vision insurance. A generous retirement savings plan, substantial paid time off, and company-paid holidays are provided. We invest in our employees' professional growth through training, conference attendance, and support for continued education. The **East London** facility provides a collaborative research environment with access to advanced tools. Employees also benefit from wellness programs and employee assistance services. This role in **East London** offers a unique opportunity to shape the early development of potentially life-saving drugs. Join our dedicated team and contribute to innovative translational research.