Senior Clinical Pharmacologist

Placements24; East London; On-site; ZAR 1,200,000 - 2,400,000; Full time

Job summary

Placements24 is seeking a Senior Clinical Pharmacologist for our client, a premier pharmaceutical research institution, to lead clinical pharmacology design and data interpretation in East London, Eastern Cape.

The role focuses on PK/PD analysis, dose optimization, and regulatory submissions, with collaboration across R&D and clinical operations in a dynamic, innovative environment.

Qualifications

• PhD in Pharmacology or related field.
• 6+ years in clinical pharmacology or drug development.
• Experience designing and analyzing PK/PD studies.
• Proficiency with PK/PD modeling software.
• Experience with regulatory submissions and interdepartmental collaboration.

Responsibilities

• Design clinical pharmacology studies (including FIH, dose-escalation, and population PK/PD).
• Develop study protocols, investigator brochures, and informed consent forms.
• Oversee conduct of studies at clinical sites, ensuring protocol/regulatory compliance.
• Analyze PK/PD data using modeling/simulation software; inform dose selection.
• Prepare integrated PK/PD summaries for regulatory submissions.

Skills

Clinical pharmacology

PK/PD modeling

Regulatory submissions

Data analysis

Cross-functional collaboration

Education

PhD in Pharmacology/related field

Tools

NONMEM

Phoenix WinNonlin

Job description

About the Role

Our client, a premier pharmaceutical research institution, is seeking a highly skilled Senior Clinical Pharmacologist to join their dedicated team in East London, Eastern Cape . This influential position is responsible for designing and overseeing clinical pharmacology studies, analyzing pharmacokinetic and pharmacodynamic data, and providing expert scientific input to drug development programs. You will play a crucial role in understanding how drugs behave in the human body, contributing to optimal dosing strategies and ensuring the safe and effective use of novel therapeutics. This is an exceptional opportunity for an experienced pharmacologist to contribute to cutting-edge research and shape the future of medicine within a supportive and innovative environment.

Key Responsibilities

Design clinical pharmacology studies, including first-in-human, dose-escalation, and population PK/PD studies. Develop study protocols, investigator brochures, and informed consent forms. Oversee the conduct of clinical pharmacology studies at clinical sites, ensuring adherence to protocols and regulatory requirements. Analyze pharmacokinetic (PK) and pharmacodynamic (PD) data using appropriate modeling and simulation software (e.g., NONMEM, Phoenix WinNonlin). Interpret PK/PD data to inform dose selection, regimen optimization, and therapeutic strategies. Prepare integrated summaries of PK and PD for regulatory submissions. Collaborate with clinical operations, biostatistics, regulatory affairs, and other R&D functions. Provide expert scientific consultation on pharmacology-related aspects of drug development projects. Stay abreast of the latest advancements in clinical pharmacology, PK/PD modeling, and drug development science. Contribute to the scientific strategy and direction of the clinical pharmacology department.

Requirements

PhD in Pharmacology, Pharmaceutical Sciences, or a related discipline, with a strong focus on clinical pharmacology. Minimum of 6 years of relevant experience in clinical pharmacology, drug development, or a related field within the pharmaceutical industry. Demonstrated expertise in designing, conducting, and analyzing clinical pharmacology studies. Proficiency in PK/PD data analysis and modeling software. In-depth understanding of regulatory requirements for clinical pharmacology studies and submissions. Excellent analytical, critical thinking, and problem-solving skills. Strong written and verbal communication skills, with the ability to present complex scientific information clearly. Ability to work effectively in a cross-functional team environment and manage multiple projects. Experience with biologics pharmacology is a plus. Commitment to scientific rigor and ethical research conduct in East London, Eastern Cape .

Benefits

Our client offers a highly competitive salary, a comprehensive benefits package including medical aid, retirement fund, and life insurance, as well as performance-based bonuses. Opportunities for continuous professional development, including attendance at international scientific conferences and specialized training programs, are actively supported. This role is based in the vibrant coastal city of East London, Eastern Cape , offering a pleasant work environment and lifestyle. Join a leading pharmaceutical organization dedicated to scientific innovation and employee growth.