Senior Clinical Data Manager - Global Trials Lead

ICON Clinical Research; Johannesburg; On-site; ZAR 900,000 - 1,300,000; Full time

Benefits offered by this job

Annual leave

Health insurance

Retirement plan

Employee assistance program (LifeWorks

Life assurance

Childcare vouchers

Job summary

ICON Strategic Solutions seeks a Senior Clinical Data Manager to act as the primary data lead across global trials, delivering regulatory-compliant data from start-up to database lock. You will drive EDC builds, system integrations, and data deliverables while overseeing data review and vendor management.

The role requires leading studies across the full lifecycle, strong CDISC/SDTM knowledge, and excellent communication and leadership skills to partner with sponsors and cross-functional teams.

Qualifications

• Bachelor's degree in Life Sciences, Health Sciences, or related discipline.
• 6+ years of Clinical Data Management or Clinical Data Science in CRO/pharma.
• Experience leading studies across full clinical trial lifecycle.
• Proven data lead on complex studies with hands-on data review across EDC, vendor, eCOA, IRT, SAE data.
• Strong vendor oversight, stakeholder management, and knowledge of CDISC standards (SDTM).

Responsibilities

• Act as the primary data lead within cross-functional study teams and sponsor partnerships.
• Drive study start-up activities including EDC build, system integrations, UAT, and data management deliverables.
• Oversee data review, reconciliation, vendor management, and database lock activities.
• Ensure compliance with CDISC standards, ICH-GCP requirements, and regulatory expectations.
• Identify and mitigate risks while driving continuous improvement and operational excellence.

Skills

Data lead leadership

EDC systems

Vendor oversight

CDISC SDTM

ICH-GCP knowledge

Communication skills

Education

Bachelor's degree in Life Sciences/Health Sciences

Tools

Veeva EDC

Job description

ICON Strategic Solutions seeks a Senior Clinical Data Manager to act as the primary data lead across global trials, delivering regulatory-compliant data from start-up to database lock. You will drive EDC builds, system integrations, and data deliverables while overseeing data review and vendor management.

The role requires leading studies across the full lifecycle, strong CDISC/SDTM knowledge, and excellent communication and leadership skills to partner with sponsors and cross-functional teams.