Senior Biophysicist - Structural Biology

Placements24; Mbombela (Nelspruit); On-site; ZAR 900,000 - 1,300,000; Full time

Benefits offered by this job

Competitive salary

Access to state-of-the-art biophysical

Relocation assistance may be available

Professional development opportunities

Core facilities access

Job summary

Placements24 is seeking a distinguished Senior Biophysicist to join its elite Structural Biology research group in Nelspruit. The role focuses on applying advanced biophysical techniques to elucidate the structures and dynamics of complex macromolecules, supporting drug discovery and disease mechanism studies.

You will lead projects, develop novel methodologies, and collaborate with biochemists, structural biologists, and computational chemists.

Qualifications

• PhD in Biophysics, Biochemistry, or related physical science discipline.
• Minimum 6 years of research experience in biophysics focusing on macromolecular interactions.
• Hands-on experience with biophysical techniques relevant to drug discovery.

Responsibilities

• Apply and develop advanced biophysical techniques including SPR, ITC, and DSF.
• Determine binding kinetics and thermodynamics of protein-ligand interactions.
• Utilize X-ray crystallography and Cryo-EM for structural projects.
• Characterize conformational stability and dynamics of biomolecules.
• Collaborate with structural biologists and computational scientists to integrate data.
• Troubleshoot experimental issues and optimize protocols.

Skills

Biophysics techniques

Protein-ligand interactions

Thermodynamics & kinetics

Education

PhD in Biophysics or Biochemistry

Tools

SPR

ITC

DSF

X-ray Crystallography

Cryo-EM

Protein Expression & Purification

Job description

About the Role

Our client is seeking a distinguished Senior Biophysicist to join their elite Structural Biology research group in Nelspruit . This crucial role will involve applying cutting-edge biophysical techniques to elucidate the structures and dynamics of complex biological macromolecules, vital for drug discovery and understanding disease mechanisms. You will lead projects, develop novel methodologies, and collaborate extensively with biochemists, structural biologists, and computational chemists. This is an exceptional opportunity for an accomplished biophysicist to contribute to significant scientific breakthroughs within a world-class research environment that fosters innovation, precision, and interdisciplinary teamwork, impacting scientific understanding from Nelspruit .

Key Responsibilities

• Apply and develop advanced biophysical techniques, including Surface Plasmon Resonance (SPR), Isothermal Titration Calorimetry (ITC), and Differential Scanning Fluorimetry (DSF).
• Determine the binding kinetics and thermodynamics of protein-ligand interactions.
• Utilize techniques such as X-ray crystallography and Cryo-EM to contribute to structural determination projects.
• Characterize the conformational stability and dynamics of proteins and other biomolecules.
• Collaborate with structural biologists and computational scientists to interpret and integrate data.
• Troubleshoot experimental issues and optimize protocols for complex biomolecular systems.

Requirements

• Ph.D. in Biophysics , Biochemistry, or a related physical science discipline.
• Minimum of 6 years of research experience in biophysics, with a focus on macromolecular interactions.
• Extensive hands-on experience with key biophysical techniques relevant to drug discovery.
• Strong theoretical understanding of thermodynamics, kinetics, and molecular interactions.
• Experience with protein expression, purification, and characterization is required.

Benefits

• Competitive salary commensurate with experience and a comprehensive benefits package.
• Access to state-of-the-art biophysical instrumentation and core facilities.
• Opportunities for professional development and contributing to high-profile publications.
• A collaborative and intellectually stimulating research environment.
• Relocation assistance may be available for candidates relocating to Nelspruit .