Senior Biophysicist: Protein Folding & Dynamics for Drug Discovery

Placements24; Vereeniging; On-site; ZAR 1,000,000 - 2,000,000; Full time

Benefits offered by this job

Health insurance

Retirement savings plan

Annual bonuses

Paid time off

Job summary

Placements24 is recruiting a Senior Biophysicist for a prestigious research institute in Vereeniging, Gauteng. You will design and execute advanced biophysical experiments to study protein structure, stability, and interactions, using a range of techniques including spectroscopy, calorimetry, SPR, and MS.

A strong publication record and cross-disciplinary collaboration are essential. The role emphasizes independent work within a multidisciplinary team, contributing to drug discovery strategies

Qualifications

• PhD in Biophysics, Biochemistry, Physical Chemistry, or related field.
• Postdoctoral or industry experience in biophysics (minimum 5 years).
• Experience with a wide range of biophysical techniques for protein analysis.
• Strong theoretical knowledge of protein structure, folding and dynamics.
• Experience with data analysis software and publications.

Responsibilities

• Design and execute sophisticated biophysical experiments to study protein structure, function, and interactions.
• Utilize spectroscopy (UV-Vis, fluorescence, CD), calorimetry (ITC, DSC), SPR, and mass spectrometry.
• Characterize protein-ligand binding kinetics and thermodynamics.
• Investigate protein folding pathways, stability, and conformational changes.
• Develop and optimize experimental protocols for biophysical characterization.
• Analyze and interpret complex biophysical datasets, drawing robust scientific conclusions.
• Collaborate with chemists, biologists, and computational scientists on research projects.
• Contribute to the writing of scientific publications, reports, and grant proposals.
• Present research findings at internal meetings and external scientific conferences.
• Maintain and operate advanced biophysical instrumentation, ensuring proper calibration and function.

Skills

Protein folding

Biophysical techniques

Data analysis

Scientific communication

Collaboration

Computational modeling

Data visualization

Education

PhD in Biophysics/Biochemistry/Physical Chemistry

Tools

MATLAB

Python

OriginPro

GraphPad Prism

ImageJ

Job description

Placements24 is recruiting a Senior Biophysicist for a prestigious research institute in Vereeniging, Gauteng. You will design and execute advanced biophysical experiments to study protein structure, stability, and interactions, using a range of techniques including spectroscopy, calorimetry, SPR, and MS.

A strong publication record and cross-disciplinary collaboration are essential. The role emphasizes independent work within a multidisciplinary team, contributing to drug discovery strategies