Principal Scientist - Drug Metabolism and Pharmacokinetics (DMPK) - Remote

Placements24; Klerksdorp; Hybride; ZAR 1 200 000 - 2 400 000; Plein temps

Avantages offerts par ce poste

Fully remote work

Health coverage

Professional development

Flexible schedule

Résumé du poste

Placements24 is seeking a Principal Scientist in Drug Metabolism and Pharmacokinetics (DMPK) to lead pivotal studies and mentor a remote team. The role supports early drug development with data-driven decision-making and cross-functional collaboration.

You will design and interpret in vivo PK and in vitro ADME studies, develop LC-MS/MS bioanalytical methods, and contribute to regulatory submissions while shaping strategic direction.

Qualifications

• PhD in Pharmacology, Pharmaceutical Sciences or Biochemistry with DMPK specialization.
• At least 8 years of progressive DMPK experience in the pharmaceutical industry.
• Experience designing, executing, and interpreting in vivo PK and in vitro ADME studies.
• Proficiency in LC-MS/MS bioanalytical method development and validation.
• Strong PK/PD modelling and simulation skills (Phoenix WinNonlin, NONMEM).
• Deep understanding of drug metabolism pathways, transporters, and clearance.
• Excellent scientific writing and presentation skills with regulatory contributions.
• Ability to lead projects and mentor junior scientists remotely.
• Collaborative, strategic thinker with multidisciplinary team experience.

Responsabilités

• Lead and design pivotal DMPK studies to characterize in vivo and in vitro behavior of drug candidates.
• Integrate and interpret data to define PK/PD relationships and inform dose selection.
• Develop and validate bioanalytical methods for quantification in biological matrices.
• Contribute to regulatory submissions by preparing DMPK data packages and study reports.
• Collaborate with discovery biology, medicinal chemistry, toxicology, and clinical pharmacology teams.
• Stay current with technologies and computational modeling in DMPK.
• Mentor and guide junior scientists within the DMPK group.
• Present research findings at internal meetings and external conferences.
• Ensure compliance with safety, ethical, and regulatory guidelines.
• Contribute to strategic direction of drug development programs.

Connaissances

DMPK leadership

ADME expertise

PK/PD modelling

Data interpretation

Remote team leadership

Scientific communication

Multidisciplinary collaboration

Study design

Bioanalysis

Regulatory contributions

Formation

PhD in Pharmacology/Pharmaceutical Sciences/Biochemistry (DMPK)

Outils

Phoenix WinNonlin

NONMEM

LC-MS/MS

Description du poste

About the Role

Our client, a trailblazer in pharmaceutical innovation, is looking for an exceptional Principal Scientist in Drug Metabolism and Pharmacokinetics (DMPK) to join their esteemed research division. This is a fully remote position, enabling you to contribute your expertise from anywhere. You will spearhead critical DMPK studies, guiding drug candidates through early development phases and ensuring their successful progression. This senior role demands a profound scientific understanding of ADME (Absorption, Distribution, Metabolism, Excretion) principles, a proven ability to design and interpret complex studies, and strong leadership skills to mentor junior scientists. As a remote-first contributor, you will collaborate seamlessly with global teams, utilizing advanced digital tools to drive research forward. This is a unique opportunity for a seasoned DMPK expert to make a substantial impact on the future of medicine within a flexible, supportive, and forward-thinking organization. We are seeking individuals who are passionate about scientific discovery and committed to excellence.

Key Responsibilities

• Lead and design pivotal DMPK studies to characterize the in vivo and in vitro behavior of novel drug candidates.
• Integrate and interpret data from various sources (e.g., bioanalysis, in vitro assays, preclinical studies) to define PK/PD relationships and inform dose selection.
• Develop and validate bioanalytical methods for the quantification of drug and metabolite concentrations in biological matrices.
• Contribute to regulatory submissions by preparing comprehensive DMPK data packages and study reports.
• Collaborate closely with discovery biology, medicinal chemistry, toxicology, and clinical pharmacology teams to provide critical DMPK insights.
• Stay abreast of cutting-edge technologies and methodologies in DMPK and computational modeling.
• Mentor and guide junior scientists and research associates within the DMPK group.
• Present research findings at internal meetings and external scientific conferences.
• Ensure compliance with all relevant safety, ethical, and regulatory guidelines.
• Contribute to the strategic direction of drug development programs.

Requirements

• PhD in Pharmacology, Pharmaceutical Sciences, Biochemistry, or a related discipline with a specialization in DMPK.
• A minimum of 8 years of progressive experience in DMPK research within the pharmaceutical industry.
• Demonstrated expertise in designing, executing, and interpreting in vivo PK studies and in vitro ADME assays.
• Strong experience with bioanalytical method development and validation using LC-MS/MS.
• Proficiency in PK/PD modelling and simulation software (e.g., Phoenix WinNonlin, NONMEM).
• Comprehensive understanding of drug metabolism pathways, transporter interactions, and clearance mechanisms.
• Excellent scientific writing and presentation skills, with a track record of publications and regulatory contributions.
• Proven ability to lead scientific projects and mentor junior team members in a remote setting.
• Exceptional problem-solving skills and strategic thinking.
• Strong collaborative abilities and experience working within multidisciplinary teams.

Benefits

Embrace the ultimate flexibility with this fully remote Principal Scientist position. Our client offers a highly competitive salary and bonus structure, along with extensive benefits including premium health coverage, retirement savings plans, and generous paid time off. Professional development is prioritized, with access to conferences, training, and opportunities for advancement. You'll be empowered with the latest technology and resources to excel in your role. This position in Klerksdorp offers the chance to be at the forefront of drug discovery from the comfort of your own home, making a significant impact on global health.