Remote Lead Research Scientist - Pharmaceutical Development

Placements24; Mossel Bay; Hybrid; ZAR 1,200,000 - 2,100,000; Full time

Benefits offered by this job

Remote work

Health insurance

Stock options

Home office allowance

Professional development

Retirement plan

Job summary

Placements24 is seeking a Remote Lead Research Scientist to drive early drug discovery for a global pharmaceutical leader. You will lead a team in designing and evaluating novel small molecule candidates and guide strategy with rigorous scientific standards.

This fully remote role requires cross‑functional collaboration, CRO oversight, and clear scientific communication. A PhD with 8+ years in medicinal chemistry and DMPK is essential to deliver results from a home office.

Qualifications

• PhD in Organic Chemistry, Medicinal Chemistry, Pharmacology, or related field.
• 8+ years of pharmaceutical R&D experience with small molecule discovery.
• Strong knowledge of medicinal chemistry, DMPK, and early-stage development.
• Proven leadership of research projects and teams.
• Excellent communication and remote collaboration skills.

Responsibilities

• Lead design and synthesis of small molecule drug candidates.
• Oversee early-stage drug discovery including in vitro and in vivo studies.
• Develop lead optimization strategies focusing on potency and DMPK.
• Collaborate with biologists, toxicologists, and formulation scientists.
• Mentor junior researchers and manage CRO partnerships.
• Prepare research reports, regulatory documents, and contribute to patents.
• Present findings to senior management and scientific boards.

Skills

Leadership

Strategic thinking

Remote teamwork

Scientific writing

Education

PhD in Organic/Medicinal Chemistry

Job description

About the Role Our client, a globally recognized pharmaceutical leader, is actively seeking an exceptional Remote Lead Research Scientist to drive innovation in pharmaceutical development. This pivotal role will involve leading a dedicated team in the design, synthesis, and evaluation of novel drug candidates. Operating in a fully remote capacity, you will leverage cutting-edge scientific methodologies and collaborate with a diverse group of experts across the globe. The ideal candidate will possess a profound understanding of medicinal chemistry, drug metabolism, and pharmacokinetic (DMPK) properties, with a proven track record of successfully bringing drug candidates through early-stage development. This is a unique opportunity to influence the future of medicine from your home office, contributing to life-changing therapies. This role is designed for maximum flexibility and impact through remote contribution.

Key Responsibilities

• Lead the design and synthesis of small molecule drug candidates targeting specific disease pathways.
• Oversee early-stage drug discovery and development activities, including in vitro and in vivo studies.
• Develop and implement strategies for lead optimization, focusing on potency, selectivity, and DMPK profiles.
• Collaborate with cross-functional teams, including biologists, toxicologists, and formulation scientists.
• Mentor and guide junior research scientists, fostering a culture of scientific rigor and innovation.
• Manage external research collaborations and contract research organizations (CROs).
• Author comprehensive research reports, regulatory documents, and contribute to patent filings.
• Present research findings to senior management and scientific advisory boards.

Requirements

• Ph.D. in Organic Chemistry, Medicinal Chemistry, Pharmacology, or a related field.
• A minimum of 8 years of experience in pharmaceutical R&D, with significant experience in small molecule drug discovery.
• Demonstrated expertise in medicinal chemistry principles and synthetic organic chemistry.
• Strong understanding of drug metabolism, pharmacokinetics (DMPK), and early-stage development processes.
• Proven experience leading research projects and managing scientific teams.
• Excellent understanding of biological assays and mechanism of action studies.
• Strong problem-solving skills and the ability to think creatively.
• Exceptional communication, interpersonal, and presentation skills.
• Experience working effectively in a remote team environment.

Benefits

• Highly competitive compensation package including salary and performance bonuses.
• Fully remote work option with flexibility in working hours.
• Comprehensive health, dental, and vision insurance.
• Significant long-term incentive plan (stock options/equity).
• Generous allowance for home office equipment and supplies.
• Opportunities for professional development and attendance at key scientific meetings.
• Retirement savings plan with company match.