Lead Synthetic Organic Chemist - Pharmaceutical Discovery

Placements24; South Africa; On-site; ZAR 1,200,000 - 1,800,000; Full time

Benefits offered by this job

Competitive pay

Incentives

Relocation assistance

Professional development

Job summary

Placements24 seeks a Lead Synthetic Organic Chemist to drive drug-discovery programs in Tembisa, Gauteng. You will design and execute multi-step syntheses of complex molecules and supervise a small team of chemists.

This role requires a PhD, 7+ years in the pharmaceutical industry, and expertise in asymmetric synthesis and method development. You will collaborate with medicinal chemists and receive strong instrumentation support.

Qualifications

• PhD in Organic Chemistry or related field required.
• Minimum 7 years hands-on experience in synthetic organic chemistry within the pharmaceutical industry.
• Proven track record in multi-step synthesis of complex molecules.

Responsibilities

• Lead design and execution of synthetic routes for complex molecules.
• Synthesize and purify target compounds and intermediates.
• Develop and optimize novel synthetic methodologies and reaction conditions.
• Characterize compounds using NMR, MS, HPLC, etc.
• Manage multiple research projects and mentor junior chemists.
• Collaborate with medicinal chemists, biologists, and pharmacologists to advance programs.

Skills

Leadership

Project management

Experimental design

Asymmetric synthesis

Multi-step synthesis

Education

PhD in Organic Chemistry

Tools

NMR

Mass spectrometry

HPLC

Job description

About the Role

Our client, a pioneering force in the pharmaceutical industry, is searching for an accomplished Lead Synthetic Organic Chemist to spearhead groundbreaking research in drug discovery. This critical role involves the design and synthesis of novel small molecules with therapeutic potential, contributing directly to the development of life-saving medications. The laboratory facilities in **Tembisa, Gauteng, ZA** are equipped with the latest technology, supporting ambitious research agendas. We seek a candidate with a passion for organic synthesis and a proven ability to lead complex projects from inception to completion. This position offers an unparalleled opportunity to influence the future of medicine and work alongside a world-class team of scientists dedicated to innovation and excellence in a **Tembisa, Gauteng, ZA** based setting.

Key Responsibilities

• Lead the design and execution of synthetic routes for complex organic molecules.
• Synthesize and purify target compounds, intermediates, and reference standards.
• Develop and optimize novel synthetic methodologies and reaction conditions.
• Characterize synthesized compounds using advanced analytical techniques (NMR, Mass Spec, HPLC, etc.).
• Interpret analytical data and troubleshoot synthetic challenges.
• Manage and prioritize multiple research projects simultaneously.
• Collaborate with medicinal chemists, biologists, and pharmacologists to advance drug discovery programs.
• Supervise and mentor junior chemists, providing guidance on synthetic strategies and laboratory techniques.
• Maintain detailed laboratory notebooks and prepare comprehensive reports for internal and external stakeholders.
• Ensure adherence to all safety protocols and laboratory operating procedures.

Requirements

• Ph.D. in Organic Chemistry or a related field.
• Minimum of 7 years of hands-on experience in synthetic organic chemistry, with a significant portion in the pharmaceutical industry.
• Demonstrated expertise in multi-step synthesis of complex molecules.
• Strong proficiency in modern organic chemistry techniques and instrumentation.
• Proven ability to design and implement novel synthetic strategies.
• Experience with asymmetric synthesis and catalysis is highly desirable.
• Excellent problem-solving skills and meticulous attention to detail.
• Strong leadership and team management capabilities.
• Excellent written and verbal communication skills for technical reporting and collaboration.
• Published research in reputable organic chemistry journals.

Benefits

Our client provides a highly competitive compensation package, including a substantial annual salary, performance incentives, and comprehensive health and wellness benefits. We offer a robust retirement plan, generous paid vacation and sick leave, and opportunities for professional development through conferences and specialized training. The state-of-the-art research facilities in **Tembisa, Gauteng, ZA** foster a stimulating and productive work environment. We value work-life balance and encourage a collaborative culture among our dedicated scientific staff. Support for relocation to the **Tembisa, Gauteng, ZA** area is available for qualified candidates. Join a team that is making a tangible difference in global health.