Lead Proteomics Research Scientist

Placements24; Cape Town; On-site; ZAR 1,800,000 - 2,800,000; Full time

Benefits offered by this job

Medical benefits

Dental benefits

Retirement plan

Annual leave

Learning opportunities

Access to equipment

Job summary

Placements24 in Cape Town invites applications for a Lead Proteomics Research Scientist to head a team of proteomics researchers in a fast‑paced biotech environment, designing LC‑MS/MS experiments and translating data into therapeutic insights.

The role requires a PhD with 7+ years in proteomics, hands‑on MS across DDA/DIA/PRM, and proven leadership to drive projects, collaborations, and publications.

Qualifications

• PhD in Biochemistry, Molecular Biology, Chemistry or related field with proteomics focus.
• 7+ years of proteomics research experience, 2+ years in leadership or supervision.
• Hands-on MS experience with DDA, DIA, PRM and related software.

Responsibilities

• Lead and mentor a team of proteomics researchers.
• Design, optimize, and execute LC-MS/MS experiments and data analysis.
• Develop new proteomic workflows and methodologies.
• Interpret large datasets to identify biomarkers and therapeutic targets.
• Collaborate with cross-functional teams to advance drug discovery.
• Oversee maintenance of high-resolution mass spectrometers.
• Contribute to publications, patents, and conferences.
• Manage project timelines, resources, and budgets.

Skills

Leadership

Proteomics

Mass spectrometry

Data analysis

Team management

Scientific publications

Education

PhD in Biochemistry, Molecular Biology, or Chemistry

Tools

MaxQuant

Spectronaut

Skyline

Job description

About the Role

Our client, a prominent biotechnology firm situated in the vibrant city of **Cape Town**, is seeking an exceptional Lead Proteomics Research Scientist. This leadership position is crucial for advancing our client's mission to develop novel therapeutic targets through sophisticated proteomic analysis. You will spearhead research initiatives, manage a team of dedicated scientists, and drive innovation in mass spectrometry-based proteomics. The role demands a strategic thinker with a profound understanding of protein science and its application in drug discovery and diagnostics. Working within a state-of-the‑art laboratory in **Cape Town, Western Cape**, you will contribute to high‑impact projects and influence the future direction of our client's research and development pipeline. This is an unparalleled opportunity for a seasoned researcher looking to lead and excel in a fast‑paced, research‑intensive environment.

Key Responsibilities

• Lead and manage a team of proteomics researchers, providing scientific guidance and mentorship.
• Design, optimize, and execute complex proteomics experiments, including sample preparation, data acquisition (LC-MS/MS), and data analysis.
• Develop novel proteomic methodologies and workflows to address specific research questions and expand capabilities.
• Interpret large-scale proteomics data, identify key biomarkers, and translate findings into biological insights and potential therapeutic strategies.
• Collaborate with cross‑functional teams, including molecular biologists, chemists, and clinicians, to advance drug discovery programs.
• Oversee the maintenance and operation of high‑resolution mass spectrometry instrumentation.
• Contribute to scientific publications, patent applications, and presentations at international conferences.
• Manage project timelines, resources, and budgets effectively.

Requirements

• PhD in Biochemistry, Molecular Biology, Chemistry, or a related field with a strong focus on proteomics.
• A minimum of 7 years of progressive research experience in proteomics, with at least 2 years in a leadership or supervisory role.
• Extensive hands‑on experience with various mass spectrometry techniques (e.g., DDA, DIA, PRM) and associated software (e.g., MaxQuant, Spectronaut, Skyline).
• Demonstrated expertise in protein sample preparation for different applications (e.g., affinity purification, global profiling, post‑translational modification analysis).
• Strong understanding of quantitative proteomics strategies.
• Proven ability to manage and mentor research staff, foster a collaborative team environment, and drive project success.
• Excellent analytical, problem‑solving, and critical thinking skills.
• Exceptional written and verbal communication skills, with a track record of scientific publications.

Benefits

• Our client offers a highly competitive remuneration package, comprehensive medical and dental benefits, a retirement savings plan, and generous annual leave.
• Employees benefit from continuous learning opportunities, access to advanced scientific equipment, and a stimulating work culture in beautiful **Cape Town**.