Lead Molecular Biologist - Protein Engineering

Placements24; Soweto; Hybrid; ZAR 1,000,000 - 1,800,000; Full time

Benefits offered by this job

Hybrid work model

Healthcare

Professional development

Competitive salary

Job summary

Placements24 in Soweto, Gauteng is seeking a Lead Molecular Biologist to drive protein engineering research, mentoring a team and guiding experimental design to deliver novel therapeutics and industrial enzymes. You will oversee cloning, expression, purification, and characterization, collaborate with cross‑functional scientists, and contribute to strategic plans while ensuring safety and compliance.

This hybrid role offers remote work option with in-lab collaboration and opportunities for

Qualifications

• PhD in Molecular Biology, Biochemistry, Bioengineering or related field.
• 7+ years of post‑doc and industry experience in molecular biology and protein engineering.
• Proven leadership experience managing scientific teams and projects.
• Hands-on experience with cloning, site-directed mutagenesis and gene synthesis.
• Expertise in protein expression systems and purification techniques.
• Experience with protein characterization methods (SDS-PAGE, Western blot, ELISA, MS).
• Knowledge of directed evolution and computational protein design.

Responsibilities

• Lead and mentor a team of molecular biologists and research associates focused on protein engineering projects.
• Design and execute experiments for protein expression, purification, characterization, and functional validation.
• Develop and implement novel strategies for protein modification, directed evolution, and rational design to enhance protein properties.
• Oversee the development of high-throughput screening assays for protein activity and stability.
• Analyze complex experimental data, interpret results, and troubleshoot technical challenges.
• Collaborate with cross-functional teams, including structural biologists, biochemists, and process development scientists.
• Contribute to the strategic planning of research programs and identify new opportunities for innovation.
• Maintain accurate laboratory notebooks and prepare detailed reports and presentations.
• Ensure compliance with all laboratory safety protocols and regulatory requirements.

Skills

Leadership

Team management

Experimental design

Data interpretation

Communication

Education

PhD in Molecular Biology or related field

Tools

Molecular cloning

Site-directed mutagenesis

Gene synthesis

Protein expression (E. coli/yeast/mammalian)

Chromatography

Protein characterization (SDS-PAGE, Western, ELISA, MS)

Job description

About the Role

Our client is seeking an experienced and visionary Lead Molecular Biologist to spearhead innovative research in protein engineering. This dynamic role, based in Soweto, Gauteng , is crucial for developing novel protein-based therapeutics and industrial enzymes. You will lead a talented team of scientists, guiding experimental design, execution, and data interpretation to achieve ambitious research goals. This position offers a unique opportunity to make significant contributions to cutting-edge biotechnology within a collaborative and forward-thinking R&D department. The ideal candidate will possess a deep understanding of molecular biology techniques and a proven track record in protein engineering.

Key Responsibilities

• Lead and mentor a team of molecular biologists and research associates focused on protein engineering projects.
• Design and execute experiments for protein expression, purification, characterization, and functional validation.
• Develop and implement novel strategies for protein modification, directed evolution, and rational design to enhance protein properties.
• Oversee the development of high-throughput screening assays for protein activity and stability.
• Analyze complex experimental data, interpret results, and troubleshoot technical challenges.
• Collaborate with cross-functional teams, including structural biologists, biochemists, and process development scientists.
• Contribute to the strategic planning of research programs and identify new opportunities for innovation.
• Maintain accurate laboratory notebooks and prepare detailed reports and presentations.
• Ensure compliance with all laboratory safety protocols and regulatory requirements.

Requirements

• PhD in Molecular Biology, Biochemistry, Bioengineering, or a related field.
• Minimum of 7 years of post-doctoral and industry experience in molecular biology and protein engineering.
• Proven leadership experience managing scientific teams and projects.
• Extensive hands-on experience with various molecular cloning techniques, site-directed mutagenesis, and gene synthesis.
• Strong expertise in protein expression systems (e.g., E. coli, yeast, mammalian cells) and protein purification techniques (e.g., chromatography).
• Proficiency in protein characterization methods (e.g., SDS-PAGE, Western Blotting, ELISA, mass spectrometry).
• Familiarity with directed evolution and computational protein design approaches.
• Excellent analytical, problem-solving, and critical thinking skills.
• Strong communication and interpersonal skills, with the ability to work effectively in a team environment.
• Experience in grant writing and publication is a plus.

Benefits

Our client offers a competitive salary, comprehensive medical, dental, and vision insurance, a retirement savings plan with company match, and generous paid time off.

This hybrid role provides the flexibility of remote work combined with essential in-lab collaboration.

Employees benefit from opportunities for professional development, continuous learning, and attendance at leading scientific conferences.

We foster a supportive work environment that encourages innovation and career growth.

This position is based in our state-of-the-art research facility in Soweto, Gauteng .